The low-density lipoprotein receptor: Ligands, debates and lore

Gabby Rudenko, Johann Deisenhofer

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Like pieces belonging to a large mosaic, the structures of low-density lipoprotein receptor (LDL-R) modules have been elucidated one by one in recent years. LDL-Rs localized on hepatocytes play an important role in removing cholesterol-transporting LDL particles from the plasma by receptor-mediated endocytosis. Key steps in this process involve the LDL-R binding LDL at neutral pH at the cell surface and, after internalization, releasing it again at acidic pH in the endosomes. How the modules of the LDL-R might interact within the intact receptor to carry out ligand binding and release has been revealed by the recent crystal structure of the extracellular domain of the LDL-R.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number6
StatePublished - Dec 2003
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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