TY - JOUR
T1 - The influence of simple aromatics on benzene clastogenicity
AU - Harper, Barbara L.
AU - Ramanujam, V. M.Sadagopa
AU - Gad-El-Karim, Mohy M.
AU - Legator, Marvin S.
N1 - Funding Information:
We are grateful to Rosalind Colley for technical assistance. This work was supported by U.S.E.P.A. Grant No. R807820.
PY - 1984/9
Y1 - 1984/9
N2 - The micronucleus test was performed in male ICR Swiss mice following modification of benzene metabolism by co-administration of aniline, pyridine or napythalene, or by prior injection of α-naphthoflavone. HPLC profiles of urinary metabolites were compared to the effects of these compounds on clastogenicity. Pyridine inhibited both benzene clastogenicity and its metabolism. Aniline and naphthalene increase the clastogenicity and slightly altered the metabolism of benzene. α-Naphthoflavone inhibited benzene increase the metabolism of benzene but noly 3-methylcholanthrene increases benzene clastogenicity, specific P450 isozymes may be responsible for different biological effects benzene, and alterations in these effects might be caused by a shift from the isozyme to another.
AB - The micronucleus test was performed in male ICR Swiss mice following modification of benzene metabolism by co-administration of aniline, pyridine or napythalene, or by prior injection of α-naphthoflavone. HPLC profiles of urinary metabolites were compared to the effects of these compounds on clastogenicity. Pyridine inhibited both benzene clastogenicity and its metabolism. Aniline and naphthalene increase the clastogenicity and slightly altered the metabolism of benzene. α-Naphthoflavone inhibited benzene increase the metabolism of benzene but noly 3-methylcholanthrene increases benzene clastogenicity, specific P450 isozymes may be responsible for different biological effects benzene, and alterations in these effects might be caused by a shift from the isozyme to another.
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U2 - 10.1016/0027-5107(84)90097-6
DO - 10.1016/0027-5107(84)90097-6
M3 - Article
C2 - 6472309
AN - SCOPUS:0021194747
SN - 0027-5107
VL - 128
SP - 105
EP - 114
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 2
ER -