The impact of renal tissue procurement at bedside on specimen adequacy and best practices

Jacob T. Wooldridge, Amy Davis, Wayne G. Fischer, Mohamed F. Khalil, Min Zhang, Marjan Afrouzian

Research output: Contribution to journalArticlepeer-review


Objectives Renal biopsy is the gold standard for the diagnosis of both native and allograft renal diseases. We studied the impact of tissue procurement at bedside (TPB) omission on the adequacy of renal biopsies. Methods We compared 120 renal biopsies collected during 2015 using TPB with 111 renal biopsies collected during 2016 when TPB was discontinued. Adequacy criteria were applied as follows: by light microscopy, 10 glomeruli and two arteries for allograft biopsies and seven glomeruli for native biopsies. At least one glomerulus was considered adequate for immunofluorescence and electron microscopy in both groups. Results The rate of inadequacies in allograft biopsies increased significantly, from 12.50% to 21.61% (P <.05), when TPB was discontinued. Conclusions Elimination of TPB service had a negative impact on allograft specimen adequacy. Repeat biopsies add cost and delay patient care. Institutions should take this into consideration when considering omission of TPB.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - Jan 7 2019


  • Adequacy
  • Biopsy
  • Nephropathology
  • Renal

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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