TY - JOUR
T1 - The hamster as an animal model for eastern equine encephalitis- and its use in studies of virus entrance into the brain
AU - Paessler, Slobodan
AU - Aguilar, Patricia
AU - Anishchenko, Michael
AU - Wang, Hui Qun
AU - Aronson, Judith
AU - Campbell, Gerald
AU - Cararra, Ann Sophie
AU - Weaver, Scott C.
N1 - Funding Information:
Received 24 April 2003; accepted 1 October 2003; electronically published 6 May 2004. Financial support: National Institutes of Health (NIH) (grant AI48807); NIH T32 Training Program in Emerging and Reemerging Infectious Diseases (AIO7536 to S.P.). Reprints or correspondence: Dr. Scott Weaver, Dept. of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0605 ([email protected]).
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Eastern equine encephalitis virus (EEEV) produces the most severe human arboviral diseases in the United States, with mortality rates of 30%-70%. Vasculitis associated with microhemorrhages in the brain dominates the pathological picture in fatal human eastern equine encephalitis, and neuronal cell death is detectable during the late stage of the disease. We describe use of the golden hamster to study EEEV-induced acute vasculitis and encephalitis. In hamsters, EEEV replicates in visceral organs, produces viremia, and penetrates the brain. The pathological manifestations and antigen distribution in the brain of a hamster are similar to those described in human cases of EEEV.
AB - Eastern equine encephalitis virus (EEEV) produces the most severe human arboviral diseases in the United States, with mortality rates of 30%-70%. Vasculitis associated with microhemorrhages in the brain dominates the pathological picture in fatal human eastern equine encephalitis, and neuronal cell death is detectable during the late stage of the disease. We describe use of the golden hamster to study EEEV-induced acute vasculitis and encephalitis. In hamsters, EEEV replicates in visceral organs, produces viremia, and penetrates the brain. The pathological manifestations and antigen distribution in the brain of a hamster are similar to those described in human cases of EEEV.
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U2 - 10.1086/383246
DO - 10.1086/383246
M3 - Article
C2 - 15143475
AN - SCOPUS:2542483381
SN - 0022-1899
VL - 189
SP - 2072
EP - 2076
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -