The gut: a key organ following injury and infection

W. W. Souba, R. M. Salloum, T. R. Austgen, M. K. Chen, V. S. Klimberg, D. A. Plumley, A. J. Pacitti, H. S. Sitren, E. M. Copeland

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The intestinal tract plays a key role in the body's response to injury and infection, both as a barrier to poisons and as a substrate processing station for the liver and other organs. Like the kidneys, heart, lungs, and liver, the gut is susceptible to dysfunction and possibly failure in certain critically ill patients. This failure is far more complex than simple ileus from bowel inactivity and disuse. Optimal support for the intestinal tract during catabolic states requires provision of appropriate nutrition, support of other organs, aggressive management of wounds, and possibly the use of newer growth factors which may have trophic effects on the gut mucosa. Enteral nutrition is currently the preferred method of feeding and should be instituted whenever feasible.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Issue number1
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Food Science
  • Nutrition and Dietetics
  • Anatomy


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