The GH/IGF-1 system in critical illness

Itoro E. Elijah; Ludwik K. Branski; Celeste C. Finnerty; David N. Herndon

doi:10.1016/j.beem.2011.06.002

The GH/IGF-1 system in critical illness

Itoro E. Elijah, Ludwik K. Branski, Celeste C. Finnerty, David N. Herndon

Surgery

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use of human recombinant Growth Hormone (rhGH) and Insulin-like Growth Factor-1 (IGF-1) - alone and in combination - has been studied extensively in preclinical and clinical trials. This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population.

Original language	English (US)
Pages (from-to)	759-767
Number of pages	9
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.beem.2011.06.002
State	Published - Oct 2011

Keywords

IGFBP-3
anabolic therapy
burns
gut atrophy
hepatic acute care response
hypermetabolism
mortality
nutrition
protein wasting
trauma

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.beem.2011.06.002

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title = "The GH/IGF-1 system in critical illness",

abstract = "The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use of human recombinant Growth Hormone (rhGH) and Insulin-like Growth Factor-1 (IGF-1) - alone and in combination - has been studied extensively in preclinical and clinical trials. This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population.",

keywords = "IGFBP-3, anabolic therapy, burns, gut atrophy, hepatic acute care response, hypermetabolism, mortality, nutrition, protein wasting, trauma",

author = "Elijah, {Itoro E.} and Branski, {Ludwik K.} and Finnerty, {Celeste C.} and Herndon, {David N.}",

note = "Funding Information: Supported by National Institutes of Health Grants P50-GM60338 , T32-GM08256 , and R01-GM056687 ; National Institute for Disability and Rehabilitation Research Grants H133A020102 , H133A70019 and H133A070026 ; and Shriners Hospital for Children Grants 8952 , 8760 , 8660 , and 8480 . LKB is supported by a Shriners Hospitals for Children Research Fellowship ( 8505 ). CCF is an ITS Career Development Scholar supported, in part, by NIH KL2RR029875 and NIH UL1RR029876 .",

year = "2011",

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doi = "10.1016/j.beem.2011.06.002",

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AU - Elijah, Itoro E.

AU - Branski, Ludwik K.

AU - Finnerty, Celeste C.

AU - Herndon, David N.

N1 - Funding Information: Supported by National Institutes of Health Grants P50-GM60338 , T32-GM08256 , and R01-GM056687 ; National Institute for Disability and Rehabilitation Research Grants H133A020102 , H133A70019 and H133A070026 ; and Shriners Hospital for Children Grants 8952 , 8760 , 8660 , and 8480 . LKB is supported by a Shriners Hospitals for Children Research Fellowship ( 8505 ). CCF is an ITS Career Development Scholar supported, in part, by NIH KL2RR029875 and NIH UL1RR029876 .

PY - 2011/10

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N2 - The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use of human recombinant Growth Hormone (rhGH) and Insulin-like Growth Factor-1 (IGF-1) - alone and in combination - has been studied extensively in preclinical and clinical trials. This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population.

AB - The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use of human recombinant Growth Hormone (rhGH) and Insulin-like Growth Factor-1 (IGF-1) - alone and in combination - has been studied extensively in preclinical and clinical trials. This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population.

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KW - anabolic therapy

KW - burns

KW - gut atrophy

KW - hepatic acute care response

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KW - mortality

KW - nutrition

KW - protein wasting

KW - trauma

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The GH/IGF-1 system in critical illness

Abstract

Keywords

ASJC Scopus subject areas

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