The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus

Samuel R. Shing; Anissa R. Ramos; Kathryn A. Patras; Angelica M. Riestra; Sinead McCabe; Victor Nizet; Alison Coady

doi:10.3389/fcimb.2019.00437

The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus

Samuel R. Shing, Anissa R. Ramos, Kathryn A. Patras, Angelica M. Riestra, Sinead McCabe, Victor Nizet, Alison Coady

Research output: Contribution to journal › Article › peer-review

Abstract

Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly. However, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus Candida albicans, a common urogenital colonizer, can promote GBS UTI. Co-inoculation of GBS with C. albicans increased bacterial adherence to bladder epithelium and promoted GBS colonization in vivo in a C. albicans adhesin-dependent manner. This study demonstrates that fungal colonization of the urogenital tract may be an important determinant of bacterial pathogenesis during UTI.

Original language	English (US)
Article number	437
Journal	Frontiers in Cellular and Infection Microbiology
Volume	9
DOIs	https://doi.org/10.3389/fcimb.2019.00437
State	Published - Jan 10 2020
Externally published	Yes

Keywords

Candida albicans
Streptococcus agalactiae
fungal-bacterial interaction
polymicrobial infection
urinary tract infection

ASJC Scopus subject areas

Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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10.3389/fcimb.2019.00437

Cite this

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title = "The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus",

abstract = "Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly. However, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus Candida albicans, a common urogenital colonizer, can promote GBS UTI. Co-inoculation of GBS with C. albicans increased bacterial adherence to bladder epithelium and promoted GBS colonization in vivo in a C. albicans adhesin-dependent manner. This study demonstrates that fungal colonization of the urogenital tract may be an important determinant of bacterial pathogenesis during UTI.",

keywords = "Candida albicans, Streptococcus agalactiae, fungal-bacterial interaction, polymicrobial infection, urinary tract infection",

author = "Shing, {Samuel R.} and Ramos, {Anissa R.} and Patras, {Kathryn A.} and Riestra, {Angelica M.} and Sinead McCabe and Victor Nizet and Alison Coady",

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day = "10",

doi = "10.3389/fcimb.2019.00437",

language = "English (US)",

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AU - Shing, Samuel R.

AU - Ramos, Anissa R.

AU - Patras, Kathryn A.

AU - Riestra, Angelica M.

AU - McCabe, Sinead

AU - Nizet, Victor

AU - Coady, Alison

PY - 2020/1/10

Y1 - 2020/1/10

N2 - Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly. However, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus Candida albicans, a common urogenital colonizer, can promote GBS UTI. Co-inoculation of GBS with C. albicans increased bacterial adherence to bladder epithelium and promoted GBS colonization in vivo in a C. albicans adhesin-dependent manner. This study demonstrates that fungal colonization of the urogenital tract may be an important determinant of bacterial pathogenesis during UTI.

AB - Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly. However, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus Candida albicans, a common urogenital colonizer, can promote GBS UTI. Co-inoculation of GBS with C. albicans increased bacterial adherence to bladder epithelium and promoted GBS colonization in vivo in a C. albicans adhesin-dependent manner. This study demonstrates that fungal colonization of the urogenital tract may be an important determinant of bacterial pathogenesis during UTI.

KW - Candida albicans

KW - Streptococcus agalactiae

KW - fungal-bacterial interaction

KW - polymicrobial infection

KW - urinary tract infection

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The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus

Abstract

Keywords

ASJC Scopus subject areas

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