The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus

Samuel R. Shing, Anissa R. Ramos, Kathryn A. Patras, Angelica M. Riestra, Sinead McCabe, Victor Nizet, Alison Coady

Research output: Contribution to journalArticlepeer-review


Group B Streptococcus (GBS) is a common cause of bacterial urinary tract infections (UTI) in susceptible populations, including pregnant women and the elderly. However, the factors that govern GBS persistence and disease severity in this niche are not fully understood. Here, we report that the presence of the fungus Candida albicans, a common urogenital colonizer, can promote GBS UTI. Co-inoculation of GBS with C. albicans increased bacterial adherence to bladder epithelium and promoted GBS colonization in vivo in a C. albicans adhesin-dependent manner. This study demonstrates that fungal colonization of the urogenital tract may be an important determinant of bacterial pathogenesis during UTI.

Original languageEnglish (US)
Article number437
JournalFrontiers in Cellular and Infection Microbiology
StatePublished - Jan 10 2020
Externally publishedYes


  • Candida albicans
  • Streptococcus agalactiae
  • fungal-bacterial interaction
  • polymicrobial infection
  • urinary tract infection

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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