The expanding spectrum of eschar-associated rickettsioses in the United States

W. Chad Cragun; Brenda L. Bartlett; Michael W. Ellis; Aaron Z. Hoover; Stephen K. Tyring; Natalia Mendoza; Todd J. Vento; William L. Nicholson; Marina E. Eremeeva; Juan P. Olano; Ronald P. Rapini; Christopher D. Paddock

doi:10.1001/archdermatol.2010.48

The expanding spectrum of eschar-associated rickettsioses in the United States

W. Chad Cragun, Brenda L. Bartlett, Michael W. Ellis, Aaron Z. Hoover, Stephen K. Tyring, Natalia Mendoza, Todd J. Vento, William L. Nicholson, Marina E. Eremeeva, Juan P. Olano, Ronald P. Rapini, Christopher D. Paddock

Pathology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Background: Until recently, Rickettsia rickettsii was the only substantiated cause of tick-borne spotted fever group (SFG) rickettsiosis in humans in the United States. Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tickborne SFG rickettsiosis. Observations:Wereport 3 cases of SFG rickettsiosis and discuss the epidemiology, clinical presentation, histopathologic features, and laboratory findings that support confirmed or probable diagnoses of R parkeri infection and describe the expanding list of eschar-associated SFG rickettsioses recognized in US patients. Conclusions: The SFG rickettsioses share many clinical manifestations and extensive antigenic cross-reactivity that may hamper specific confirmation of the causative agent.

Original language	English (US)
Pages (from-to)	641-648
Number of pages	8
Journal	Archives of dermatology
Volume	146
Issue number	6
DOIs	https://doi.org/10.1001/archdermatol.2010.48
State	Published - Jun 2010

ASJC Scopus subject areas

Dermatology

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10.1001/archdermatol.2010.48

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title = "The expanding spectrum of eschar-associated rickettsioses in the United States",

abstract = "Background: Until recently, Rickettsia rickettsii was the only substantiated cause of tick-borne spotted fever group (SFG) rickettsiosis in humans in the United States. Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tickborne SFG rickettsiosis. Observations:Wereport 3 cases of SFG rickettsiosis and discuss the epidemiology, clinical presentation, histopathologic features, and laboratory findings that support confirmed or probable diagnoses of R parkeri infection and describe the expanding list of eschar-associated SFG rickettsioses recognized in US patients. Conclusions: The SFG rickettsioses share many clinical manifestations and extensive antigenic cross-reactivity that may hamper specific confirmation of the causative agent.",

author = "Cragun, {W. Chad} and Bartlett, {Brenda L.} and Ellis, {Michael W.} and Hoover, {Aaron Z.} and Tyring, {Stephen K.} and Natalia Mendoza and Vento, {Todd J.} and Nicholson, {William L.} and Eremeeva, {Marina E.} and Olano, {Juan P.} and Rapini, {Ronald P.} and Paddock, {Christopher D.}",

year = "2010",

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AU - Bartlett, Brenda L.

AU - Ellis, Michael W.

AU - Hoover, Aaron Z.

AU - Tyring, Stephen K.

AU - Mendoza, Natalia

AU - Vento, Todd J.

AU - Nicholson, William L.

AU - Eremeeva, Marina E.

AU - Olano, Juan P.

AU - Rapini, Ronald P.

AU - Paddock, Christopher D.

PY - 2010/6

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N2 - Background: Until recently, Rickettsia rickettsii was the only substantiated cause of tick-borne spotted fever group (SFG) rickettsiosis in humans in the United States. Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tickborne SFG rickettsiosis. Observations:Wereport 3 cases of SFG rickettsiosis and discuss the epidemiology, clinical presentation, histopathologic features, and laboratory findings that support confirmed or probable diagnoses of R parkeri infection and describe the expanding list of eschar-associated SFG rickettsioses recognized in US patients. Conclusions: The SFG rickettsioses share many clinical manifestations and extensive antigenic cross-reactivity that may hamper specific confirmation of the causative agent.

AB - Background: Until recently, Rickettsia rickettsii was the only substantiated cause of tick-borne spotted fever group (SFG) rickettsiosis in humans in the United States. Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tickborne SFG rickettsiosis. Observations:Wereport 3 cases of SFG rickettsiosis and discuss the epidemiology, clinical presentation, histopathologic features, and laboratory findings that support confirmed or probable diagnoses of R parkeri infection and describe the expanding list of eschar-associated SFG rickettsioses recognized in US patients. Conclusions: The SFG rickettsioses share many clinical manifestations and extensive antigenic cross-reactivity that may hamper specific confirmation of the causative agent.

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The expanding spectrum of eschar-associated rickettsioses in the United States

Abstract

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