The evolutionary genetics and emergence of avian influenza viruses in wild birds

Vivien G. Dugan; Rubing Chen; David J. Spiro; Naomi Sengamalay; Jennifer Zaborsky; Elodie Ghedin; Jacqueline Nolting; David E. Swayne; Jonathan A. Runstadler; George M. Happ; Dennis A. Senne; Ruixue Wang; Richard D. Slemons; Edward C. Holmes; Jeffery K. Taubenberger

doi:10.1371/journal.ppat.1000076

The evolutionary genetics and emergence of avian influenza viruses in wild birds

Vivien G. Dugan, Rubing Chen, David J. Spiro, Naomi Sengamalay, Jennifer Zaborsky, Elodie Ghedin, Jacqueline Nolting, David E. Swayne, Jonathan A. Runstadler, George M. Happ, Dennis A. Senne, Ruixue Wang, Richard D. Slemons, Edward C. Holmes, Jeffery K. Taubenberger

Research output: Contribution to journal › Article › peer-review

267 Scopus citations

Abstract

We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient "genome constellations," continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses.

Original language	English (US)
Article number	e1000076
Journal	PLoS pathogens
Volume	4
Issue number	5
DOIs	https://doi.org/10.1371/journal.ppat.1000076
State	Published - May 2008
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Molecular Biology
Genetics
Virology

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10.1371/journal.ppat.1000076

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Dugan, V. G., Chen, R., Spiro, D. J., Sengamalay, N., Zaborsky, J., Ghedin, E., Nolting, J., Swayne, D. E., Runstadler, J. A., Happ, G. M., Senne, D. A., Wang, R., Slemons, R. D., Holmes, E. C., & Taubenberger, J. K. (2008). The evolutionary genetics and emergence of avian influenza viruses in wild birds. PLoS pathogens, 4(5), Article e1000076. https://doi.org/10.1371/journal.ppat.1000076

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abstract = "We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient {"}genome constellations,{"} continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses.",

author = "Dugan, {Vivien G.} and Rubing Chen and Spiro, {David J.} and Naomi Sengamalay and Jennifer Zaborsky and Elodie Ghedin and Jacqueline Nolting and Swayne, {David E.} and Runstadler, {Jonathan A.} and Happ, {George M.} and Senne, {Dennis A.} and Ruixue Wang and Slemons, {Richard D.} and Holmes, {Edward C.} and Taubenberger, {Jeffery K.}",

note = "Funding Information: Over the last 22 years, the virus repository used in this study received financial support from the USDA CSREES NRI, US Poultry and Egg Association, and the USDA ARS. Also, many individuals associated with the Ohio and Maryland Departments of Natural Resources, the Missouri Avian Influenza Task Force, and several Ohio and Maryland shooting clubs provided expertise, time, and physical support for this project.",

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The evolutionary genetics and emergence of avian influenza viruses in wild birds

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