The endogenous sub-type of depression: A study of its internal construct validity

M. A. Young, W. A. Scheftner, G. L. Klerman, N. C. Andreasen, R. M. Hirschfeld

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


The internal construct validity of the endogenous sub-type of major depression was investigated by statistically modelling the RDC endogenous and DSM-III melancholia diagnostic criteria. Data consisted of symptom ratings on 788 patients with major depression from NIMH Collaborative Depression Study. Results indicated that the symptoms in the criteria do not specify a dichotomous classification, melancholic-non-melancholic or endogenous-nonendogenous. Results did not support the existance of two sub-typings, one related to anhedonia, and one related to vegetative symptoms. The vegetative sub-type rarely occurred in non-anhedonic patients. Previous studies may have found support for a simple endogenous sub-type because of this hierarchical relationship and as a result of methodological differences.

Original languageEnglish (US)
Pages (from-to)257-267
Number of pages11
JournalBritish Journal of Psychiatry
Issue numberMAR.
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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