Abstract
While the effect of sex steroids on growth is well known, their effects on somatomedin C, a mediator of growth, are unclear. To investigate the effect of sex steroids on somatomedin C (Sm-C) concentrations, Sm-C was measured in adults receiving pharmacological doses of various sex steroids (estrogens, testosterone, and medroxyprogesterone acetate). Testosterone therapy had no effect on the somatomedin C concentration. Although both estrogen and medroxyprogesterone acetate therapy reduced the plasma testosterone concentration into the normal female range, they had different effects on Sm-C concentrations. Estrogen therapy produced no detectable change in the Sm-C concentration; medroxyprogesterone acetate caused an increase in the plasma somatomedin C concentration (P < 0.001). Since medroxyprogesterone acetate also does not increase the serum GH concentration, other mechanisms by which medroxyprogesterone acetate stimulates Sm-C production are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1184-1187 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 55 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical