TY - JOUR
T1 - The effect of deletion of a conserved 11 nucleotide sequence on mouse hepatitis virus RNA replication
AU - Repass, J. F.
AU - Makino, S.
PY - 1998
Y1 - 1998
N2 - A conserved 11 nt sequence present at near the 3' end of mouse hepatitis virus (MHV) genomic RNA binds to host proteins and is important for MHV RNA replication (Yu and Leibowitz, 1995). To better understand the role of this 11 nt sequence in positive-strand MHV RNA replication, we examined whether positive-strand MHV DI RNAs from negative-strand DI RNA transcripts lacking the 11 nt sequence were synthesized in MHV-infected cells. Positive-strand DI RNAs did not accumulate efficiently, indicating that the conserved 11 nt sequence was necessary for positive-strand MHV RNA synthesis.
AB - A conserved 11 nt sequence present at near the 3' end of mouse hepatitis virus (MHV) genomic RNA binds to host proteins and is important for MHV RNA replication (Yu and Leibowitz, 1995). To better understand the role of this 11 nt sequence in positive-strand MHV RNA replication, we examined whether positive-strand MHV DI RNAs from negative-strand DI RNA transcripts lacking the 11 nt sequence were synthesized in MHV-infected cells. Positive-strand DI RNAs did not accumulate efficiently, indicating that the conserved 11 nt sequence was necessary for positive-strand MHV RNA synthesis.
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U2 - 10.1007/978-1-4615-5331-1_31
DO - 10.1007/978-1-4615-5331-1_31
M3 - Article
C2 - 9782288
AN - SCOPUS:0031720832
SN - 0065-2598
VL - 440
SP - 247
EP - 252
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -