The effect of cytosine arabinoside on platelet aggregation

Robert G. Gagliano; Anne M. Terrebonne; Jack B. Alperin; John J. Costanzi

doi:10.1002/1097-0142(197612)38:6<2247::AID-CNCR2820380609>3.0.CO;2-Z

The effect of cytosine arabinoside on platelet aggregation

Robert G. Gagliano, Anne M. Terrebonne, Jack B. Alperin, John J. Costanzi

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Platelet aggregation induced by ADP, collagen, epinephrine, and thrombin was studied in patients with acute leukemia in complete remission, before and after a continuous 5‐day intravenous infusion of cytosine arabinoside at a dose of 100 mg/m² per day. Aggregation was also measured in normal subjects with cytosine arabinoside added in vitro. Cytosine arabinoside had no significant effect on platelet aggregation after either in vitro or in vivo administration.

Original language	English (US)
Pages (from-to)	2247-2249
Number of pages	3
Journal	Cancer
Volume	38
Issue number	6
DOIs	https://doi.org/10.1002/1097-0142(197612)38:6<2247::AID-CNCR2820380609>3.0.CO;2-Z
State	Published - Dec 1976
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(197612)38:6<2247::AID-CNCR2820380609>3.0.CO;2-Z

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author = "Gagliano, {Robert G.} and Terrebonne, {Anne M.} and Alperin, {Jack B.} and Costanzi, {John J.}",

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AU - Terrebonne, Anne M.

AU - Alperin, Jack B.

AU - Costanzi, John J.

PY - 1976/12

Y1 - 1976/12

N2 - Platelet aggregation induced by ADP, collagen, epinephrine, and thrombin was studied in patients with acute leukemia in complete remission, before and after a continuous 5‐day intravenous infusion of cytosine arabinoside at a dose of 100 mg/m2 per day. Aggregation was also measured in normal subjects with cytosine arabinoside added in vitro. Cytosine arabinoside had no significant effect on platelet aggregation after either in vitro or in vivo administration.

AB - Platelet aggregation induced by ADP, collagen, epinephrine, and thrombin was studied in patients with acute leukemia in complete remission, before and after a continuous 5‐day intravenous infusion of cytosine arabinoside at a dose of 100 mg/m2 per day. Aggregation was also measured in normal subjects with cytosine arabinoside added in vitro. Cytosine arabinoside had no significant effect on platelet aggregation after either in vitro or in vivo administration.

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The effect of cytosine arabinoside on platelet aggregation

Abstract

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