The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro

Gui Fang Jin; Yan Shi Guo; Edward R. Smith; Clifford W. Houston

doi:10.1016/0196-9781(90)90098-P

The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro

Gui Fang Jin, Yan Shi Guo, Edward R. Smith, Clifford W. Houston

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic function of mouse phagocytes. BBS-related peptides, gastrin-releasing peptides (GRP)-27, GRP-14, GRP-10 and neuromedin B, also induced similar CL responses compared with BBS. The CL response elicited by BBS was depressed dramatically by various concentration of EGTA (a Ca⁺⁺ chelator), indicating that a Ca⁺⁺ pathway may play a key role in the BBS-stimulated CL response.

Original language	English (US)
Pages (from-to)	393-396
Number of pages	4
Journal	Peptides
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(90)90098-P
State	Published - 1990
Externally published	Yes

Keywords

Bombesin
Ca
Chemiluminescence
GRP
Neuromedin B
Phagocytic cells

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(90)90098-P

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title = "The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro",

abstract = "Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic function of mouse phagocytes. BBS-related peptides, gastrin-releasing peptides (GRP)-27, GRP-14, GRP-10 and neuromedin B, also induced similar CL responses compared with BBS. The CL response elicited by BBS was depressed dramatically by various concentration of EGTA (a Ca++ chelator), indicating that a Ca++ pathway may play a key role in the BBS-stimulated CL response.",

keywords = "Bombesin, Ca, Chemiluminescence, GRP, Neuromedin B, Phagocytic cells",

author = "Jin, {Gui Fang} and Guo, {Yan Shi} and Smith, {Edward R.} and Houston, {Clifford W.}",

year = "1990",

doi = "10.1016/0196-9781(90)90098-P",

language = "English (US)",

volume = "11",

pages = "393--396",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro

AU - Jin, Gui Fang

AU - Guo, Yan Shi

AU - Smith, Edward R.

AU - Houston, Clifford W.

PY - 1990

Y1 - 1990

N2 - Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic function of mouse phagocytes. BBS-related peptides, gastrin-releasing peptides (GRP)-27, GRP-14, GRP-10 and neuromedin B, also induced similar CL responses compared with BBS. The CL response elicited by BBS was depressed dramatically by various concentration of EGTA (a Ca++ chelator), indicating that a Ca++ pathway may play a key role in the BBS-stimulated CL response.

AB - Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic function of mouse phagocytes. BBS-related peptides, gastrin-releasing peptides (GRP)-27, GRP-14, GRP-10 and neuromedin B, also induced similar CL responses compared with BBS. The CL response elicited by BBS was depressed dramatically by various concentration of EGTA (a Ca++ chelator), indicating that a Ca++ pathway may play a key role in the BBS-stimulated CL response.

KW - Bombesin

KW - Ca

KW - Chemiluminescence

KW - GRP

KW - Neuromedin B

KW - Phagocytic cells

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JO - Peptides

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The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro

Abstract

Keywords

ASJC Scopus subject areas

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