Abstract
T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV+ subjects had a total T-reg percent that is 2.8% (p = 0.02) higher than among younger HIV+, older HIV- and younger HIV- subjects. In HIV+ subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r = - 0.45, p = 0.002) and Candida (r = - 0.43, p = 0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV+ subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV+ population and may play a role in the accelerated disease progression seen in older HIV-infected persons.
Original language | English (US) |
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Pages (from-to) | 298-303 |
Number of pages | 6 |
Journal | Clinical Immunology |
Volume | 130 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2009 |
Externally published | Yes |
Keywords
- Aging
- HIV
- T-regulatory cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology