The development and genetic diversity of H5N1 influenza virus in China, 1996-2006

L. Duan; J. Bahl; G. J.D. Smith; J. Wang; D. Vijaykrishna; L. J. Zhang; J. X. Zhang; K. S. Li; X. H. Fan; C. L. Cheung; K. Huang; L. L.M. Poon; K. F. Shortridge; R. G. Webster; J. S.M. Peiris; H. Chen; Y. Guan

doi:10.1016/j.virol.2008.07.038

The development and genetic diversity of H5N1 influenza virus in China, 1996-2006

L. Duan, J. Bahl, G. J.D. Smith, J. Wang, D. Vijaykrishna, L. J. Zhang, J. X. Zhang, K. S. Li, X. H. Fan, C. L. Cheung, K. Huang, L. L.M. Poon, K. F. Shortridge, R. G. Webster, J. S.M. Peiris, H. Chen, Y. Guan

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.

Original language	English (US)
Pages (from-to)	243-254
Number of pages	12
Journal	Virology
Volume	380
Issue number	2
DOIs	https://doi.org/10.1016/j.virol.2008.07.038
State	Published - Oct 25 2008
Externally published	Yes

Keywords

Avian influenza
Genotype
Reassortant

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2008.07.038

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Duan, L., Bahl, J., Smith, G. J. D., Wang, J., Vijaykrishna, D., Zhang, L. J., Zhang, J. X., Li, K. S., Fan, X. H., Cheung, C. L., Huang, K., Poon, L. L. M., Shortridge, K. F., Webster, R. G., Peiris, J. S. M., Chen, H., & Guan, Y. (2008). The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology, 380(2), 243-254. https://doi.org/10.1016/j.virol.2008.07.038

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title = "The development and genetic diversity of H5N1 influenza virus in China, 1996-2006",

abstract = "Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.",

keywords = "Avian influenza, Genotype, Reassortant",

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note = "Funding Information: This study was supported by the Li Ka Shing Foundation, the National Institutes of Health (NIAID contract HHSN266200700005C), and the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06) of the Hong Kong SAR Government. ",

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AU - Duan, L.

AU - Bahl, J.

AU - Smith, G. J.D.

AU - Wang, J.

AU - Vijaykrishna, D.

AU - Zhang, L. J.

AU - Zhang, J. X.

AU - Li, K. S.

AU - Fan, X. H.

AU - Cheung, C. L.

AU - Huang, K.

AU - Poon, L. L.M.

AU - Shortridge, K. F.

AU - Webster, R. G.

AU - Peiris, J. S.M.

AU - Chen, H.

AU - Guan, Y.

N1 - Funding Information: This study was supported by the Li Ka Shing Foundation, the National Institutes of Health (NIAID contract HHSN266200700005C), and the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06) of the Hong Kong SAR Government.

PY - 2008/10/25

Y1 - 2008/10/25

N2 - Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.

AB - Since it was first detected in 1996, the Goose/Guangdong/1/1996 (Gs/GD) H5N1 influenza virus and its reassortants have spread to over 60 countries, with over 20 distinct genetic reassortants previously recognized. However, systematic analysis of their interrelationship and the development of genetic diversity have not been explored. As each of those reassortants was first detected in China, here 318 full-length H5N1 virus genomes isolated from 1996 to 2006 in this region were phylogenetically analyzed. Our findings revealed two major group reassortment events in 2001 and 2002 that were responsible for the generation of the majority of the 44 distinct Gs/GD genotypes identified, excepting those 1997 variants. Genotype replacement and emergence occurred continually, with 34 transient genotypes detected while only 10 variants were persistent. Two major replacements of predominant genotypes were also observed: genotype B replaced by Z in 2002 and then genotype Z replaced by the now predominant genotype V in 2005.

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The development and genetic diversity of H5N1 influenza virus in China, 1996-2006

Abstract

Keywords

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