The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

Yane Shih Wang; William K. Russell; Zhiyong Wang; Wei Wan; Lindsey E. Dodd; Pei Jing Pai; David H. Russell; Wenshe R. Liu

doi:10.1039/c0mb00217h

The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

Yane Shih Wang, William K. Russell, Zhiyong Wang, Wei Wan, Lindsey E. Dodd, Pei Jing Pai, David H. Russell, Wenshe R. Liu

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Using evolved pyrrolysyl-tRNA synthetase-tRNAPylCUA pairs, l-phenylalanine, p-iodo-l-phenylalanine and p-bromo-l-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

Original language	English (US)
Pages (from-to)	714-717
Number of pages	4
Journal	Molecular BioSystems
Volume	7
Issue number	3
DOIs	https://doi.org/10.1039/c0mb00217h
State	Published - Mar 1 2011
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Molecular Biology

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title = "The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives",

abstract = "Using evolved pyrrolysyl-tRNA synthetase-tRNAPylCUA pairs, l-phenylalanine, p-iodo-l-phenylalanine and p-bromo-l-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.",

author = "Wang, {Yane Shih} and Russell, {William K.} and Zhiyong Wang and Wei Wan and Dodd, {Lindsey E.} and Pai, {Pei Jing} and Russell, {David H.} and Liu, {Wenshe R.}",

year = "2011",

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doi = "10.1039/c0mb00217h",

language = "English (US)",

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pages = "714--717",

journal = "Molecular BioSystems",

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T1 - The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

AU - Wang, Yane Shih

AU - Russell, William K.

AU - Wang, Zhiyong

AU - Wan, Wei

AU - Dodd, Lindsey E.

AU - Pai, Pei Jing

AU - Russell, David H.

AU - Liu, Wenshe R.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Using evolved pyrrolysyl-tRNA synthetase-tRNAPylCUA pairs, l-phenylalanine, p-iodo-l-phenylalanine and p-bromo-l-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

AB - Using evolved pyrrolysyl-tRNA synthetase-tRNAPylCUA pairs, l-phenylalanine, p-iodo-l-phenylalanine and p-bromo-l-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

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DO - 10.1039/c0mb00217h

M3 - Article

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The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

Abstract

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