The clinical utility and assessment of renal biomarkers in acute kidney injury after abdominal endovascular aneurysm repair. A systematic review

Georgios Karaolanis, Zachary F. Williams, Chris Bakoyiannis, Dimitrios Hadjis, Mitchell W. Cox, Dimitrios Moris

Research output: Contribution to journalReview articlepeer-review


The widespread adoption of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) is due to the obvious advantages of the procedure compared to the traditional open repair. However, these advantages have to be weighed against the increased risk of renal dysfunction with EVAR. The evaluation of the perioperative renal function after EVAR has been hampered by the lack of sensitive and specific biochemical markers of acute kidney injury (AKI). The purpose of this study was to summarize all novel renal biomarkers and to evaluate their clinical utility for the assessment of the kidney function after EVAR. A systematic review of the current literature, as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines, was performed to identify relevant studies with novel renal biomarkers and EVAR. Pubmed and Scopus databases were systemically searched. Studies reporting on thoracic endovascular aortic repair (TEVAR), case reports, case series, letters to the editor, and systematic reviews were excluded. Neutrophil-Gelatinase-Associated Lipocalin, Cystatin C, Liver-type fatty-acid-binding protein were the most common among the eligible studies while Interleukin-18, Retinol binding protein, N-acetyle-b-D-glucosaminidase and microalbumin have a sparse appearance in the literature. These biomarkers have been assessed in plasma as well as urine samples with each sample material having its own advantages and drawbacks. Which of these biomarkers has the most potential for assessing postoperative renal failure after EVAR, remains to be proved. The few studies presented in the literature show the potential clinical utility of these biomarkers, but larger studies with longer follow-up are required to determine the precise relationship between these biomarkers and postoperative acute kidney injury.

Original languageEnglish (US)
Pages (from-to)4695-4701
Number of pages7
JournalCurrent Pharmaceutical Design
Issue number44
StatePublished - 2019
Externally publishedYes


  • Abdominal aortic aneurysm
  • Acute kidney injury
  • Biomarkers
  • Endovascular repair
  • Systematic review
  • Systematic reviews and meta-analyses

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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