Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men

Kelli Blackwell; Michele Blackwell; Thomas Blackwell

doi:10.1007/s11886-023-01935-1

Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men

Kelli Blackwell, Michele Blackwell, Thomas Blackwell

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Purpose of Review: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis. Summary: The use of TRT to achieve physiologic testosterone concentrations in men does not pose a threat to CV health and has demonstrated a cardioprotective effect.

Original language	English (US)
Pages (from-to)	1157-1163
Number of pages	7
Journal	Current Cardiology Reports
Volume	25
Issue number	10
DOIs	https://doi.org/10.1007/s11886-023-01935-1
State	Published - Oct 2023

Keywords

Cardiovascular disease
Heart
Hypogonadal men
Myocardial infarction
Testosterone
Testosterone replacement therapy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11886-023-01935-1

Cite this

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title = "Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men",

abstract = "Purpose of Review: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis. Summary: The use of TRT to achieve physiologic testosterone concentrations in men does not pose a threat to CV health and has demonstrated a cardioprotective effect.",

keywords = "Cardiovascular disease, Heart, Hypogonadal men, Myocardial infarction, Testosterone, Testosterone replacement therapy",

author = "Kelli Blackwell and Michele Blackwell and Thomas Blackwell",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s11886-023-01935-1",

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journal = "Current Cardiology Reports",

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T1 - Testosterone Replacement Therapy and Cardiovascular Disease

T2 - Balancing Safety and Risks in Hypogonadal Men

AU - Blackwell, Kelli

AU - Blackwell, Michele

AU - Blackwell, Thomas

PY - 2023/10

Y1 - 2023/10

N2 - Purpose of Review: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis. Summary: The use of TRT to achieve physiologic testosterone concentrations in men does not pose a threat to CV health and has demonstrated a cardioprotective effect.

AB - Purpose of Review: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis. Summary: The use of TRT to achieve physiologic testosterone concentrations in men does not pose a threat to CV health and has demonstrated a cardioprotective effect.

KW - Cardiovascular disease

KW - Heart

KW - Hypogonadal men

KW - Myocardial infarction

KW - Testosterone

KW - Testosterone replacement therapy

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Testosterone Replacement Therapy and Cardiovascular Disease: Balancing Safety and Risks in Hypogonadal Men

Abstract

Keywords

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