Terrestrial analogs for Spaceflight Associated Neuro-Ocular Syndrome

Giovanni Taibbi, Gianmarco Vizzeri

Research output: Chapter in Book/Report/Conference proceedingChapter


Given the unique challenges of conducting research in space, sophisticated platforms known as “microgravity analogs” are used on earth to closely mimic outer space. This chapter illustrates the three main terrestrial analogs for the study of Spaceflight Associated Neuro-Ocular Syndrome (SANS): parabolic flight, dry immersion, and head-down tilt bed rest (HDTBR). While brief periods of microgravity can only be experienced during parabolic flight, HDTBR remains the most popular terrestrial analog. SANS signs and symptoms have not been fully replicated on earth; however, analog-based research may be used to generate pathophysiological hypotheses, validate and test new instrumentation, and evaluate candidate SANS countermeasures.

Original languageEnglish (US)
Title of host publicationSpaceflight Associated Neuro-Ocular Syndrome
Number of pages6
ISBN (Electronic)9780323915243
ISBN (Print)9780323915250
StatePublished - Jan 1 2022


  • Dry immersion
  • Head-down tilt bed rest
  • Microgravity
  • Parabolic flight
  • Spaceflight Associated Neuro-Ocular Syndrome

ASJC Scopus subject areas

  • General Medicine


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