Temporal Trends and Outcomes of Elective Thoracic Aortic Repair and Acute Aortic Syndromes in Bicuspid Aortic Valves: Insights from a National Database

Ayman Elbadawi, Ahmad A. Mahmoud, Karim Mahmoud, Islam Y. Elgendy, Mohmed A. Omer, Ahmed Elsherbeny, Gbolahan O. Ogunbayo, Scott J. Cameron, Ravi Ghanta, David Paniagua, Ernesto Jimenez, Hani Jneid

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: There is paucity of data on the outcomes of hospitalization for bicuspid aortic valve (BAV)-related aortopathies. Methods: We queried the NIS database (2012–2016) for hospitalizations for elective thoracic aortic repair or acute aortic syndrome (AAS) among those with BAV versus trileaflet aortic valve (TAV). Results: Our analysis yielded 38,010 hospitalizations for elective aortic repair, of whom 34.4% had BAV, as well as 81,875 hospitalizations for thoracic AAS, of whom 1.1% had BAV. Hospitalizations for BAV were younger and had fewer comorbidities compared with their TAV counterparts. The number of hospitalizations for BAV during the observational period was unchanged. After propensity matching, elective aortic repair for BAV was associated with lower mortality (0.5% versus 1.7%, odds ratio = 0.28; 95% CI 1.5–0.50, p < 0.001), use of mechanical circulatory support, acute stroke, and shorter length of hospital stay compared with TAV. After propensity matching, AAS among those with BAV had a greater incidence of bleeding events, blood transfusion, cardiac tamponade, ventricular arrhythmias, and a longer length of hospital stay compared with TAV. Among those with BAV, predictors of lower mortality if undergoing elective aortic repair included larger hospitals and teaching hospitals. Predictors of higher mortality in patients with AAS included heart failure, chronic kidney disease, and coronary artery disease. Conclusion: Data from a national database showed no change in the number of hospitalizations for BAV-related aortopathy, with relatively lower incidence of AAS. Compared with TAV, elective aortic repair for BAV is associated with lower mortality, while BAV-related AAS is associated with higher in-hospital complications.

Original languageEnglish (US)
Pages (from-to)531-545
Number of pages15
JournalCardiology and Therapy
Volume10
Issue number2
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • Acute aortic syndrome
  • Aortic aneurysm
  • Aortic repair

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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