TC3A: The Cancer 3′ UTR Atlas

Xin Feng, Lei Li, Eric J. Wagner, Wei Li

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Widespread alternative polyadenylation (APA) occurs during enhanced cellular proliferation and transformation. Recently, we demonstrated that CFIm25-mediated 3′ UTR shortening through APA promotes glioblastoma tumor growth in vitro and in vivo, further underscoring its significance to tumorigenesis. Here, we report The Cancer 3′ UTR Atlas (TC3A), a comprehensive resource of APA usage for 10,537 tumors across 32 cancer types. These APA events represent potentially novel prognostic biomarkers and may uncover novel mechanisms for the regulation of cancer driver genes. TC3A is built on top of the now de facto standard cBioPortal. Therefore, the large community of existing cBioPortal users and clinical researchers will find TC3A familiar and immediately usable. TC3A is currently fully functional and freely available at

Original languageEnglish (US)
Pages (from-to)D1027-D1030
JournalNucleic acids research
Issue numberD1
StatePublished - Jan 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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