Task force report on “non-criteria” antiphospholipid antibody tests

Maria Laur A. Bertolaccini, Olg A. Amengual, Tatsuy A. Atsumi, Walter L. Binder, William H. Kutteh, Bas De Laat, Ricardo Forastiero, Marc Lambert, Hidehiko Matsubayashi, Vijaya L. Murthy, Michelle Petri, Jacob H. Rand, Marielle Sanmarco, Anne E. Tebo, Silvia S. Pierangeli

Research output: Chapter in Book/Report/Conference proceedingChapter


Current classification criteria for antiphospholipid syndrome (APS) recommend the use of one or more of three positive standardized laboratory assays to detect antiphospholipid antibodies (aPL) in the presence of at least one of the two major clinical manifestations (i.e., thrombosis or pregnancy morbidity). However, several other autoantibodies shown to be directed against phospholipids other than cardiolipin and/or their complexes with proteins of the coagulation cascade have also been proposed to be important in APS. This chapter summarizes the recommendations of a Task Force of worldwide scientists who discussed and analyzed critical questions related to “noncriteria” aPL tests in an evidence-based manner, during the 13th International Congress on Antiphospholipid Antibodies (APLA 2010, April 13–16, 2010, Galveston, TX).

Original languageEnglish (US)
Title of host publicationAntiphospholipid Syndrome
Subtitle of host publicationInsights and Highlights from the 13Th International Congress on Antiphospholipid Antibodies
PublisherSpringer US
Number of pages13
ISBN (Electronic)9781461431947
ISBN (Print)9781461431930
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • General Medicine


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