Targeting aggrephagy for the treatment of Alzheimer’s disease

Sandeep Malampati; Ju Xian Song; Benjamin Chun Kit Tong; Anusha Nalluri; Chuan Bin Yang; Ziying Wang; Sravan Gopalkrishnashetty Sreenivasmurthy; Zhou Zhu; Jia Liu; Chengfu Su; Senthilkumar Krishnamoorthi; Ashok Iyaswamy; King Ho Cheung; Jia Hong Lu; Min Li

doi:10.3390/cells9020311

Targeting aggrephagy for the treatment of Alzheimer’s disease

Sandeep Malampati, Ju Xian Song, Benjamin Chun Kit Tong, Anusha Nalluri, Chuan Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King Ho Cheung, Jia Hong Lu, Min Li

Research output: Contribution to journal › Review article › peer-review

Abstract

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.

Original language	English (US)
Article number	311
Journal	Cells
Volume	9
Issue number	2
DOIs	https://doi.org/10.3390/cells9020311
State	Published - Feb 2020
Externally published	Yes

Keywords

Aggregates
Aggrephagy
Alzheimer’s disease
Selective autophagy

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells9020311

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title = "Targeting aggrephagy for the treatment of Alzheimer{\textquoteright}s disease",

abstract = "Alzheimer{\textquoteright}s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.",

keywords = "Aggregates, Aggrephagy, Alzheimer{\textquoteright}s disease, Selective autophagy",

author = "Sandeep Malampati and Song, {Ju Xian} and Tong, {Benjamin Chun Kit} and Anusha Nalluri and Yang, {Chuan Bin} and Ziying Wang and Sreenivasmurthy, {Sravan Gopalkrishnashetty} and Zhou Zhu and Jia Liu and Chengfu Su and Senthilkumar Krishnamoorthi and Ashok Iyaswamy and Cheung, {King Ho} and Lu, {Jia Hong} and Min Li",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = feb,

doi = "10.3390/cells9020311",

language = "English (US)",

volume = "9",

journal = "Cells",

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AU - Malampati, Sandeep

AU - Song, Ju Xian

AU - Tong, Benjamin Chun Kit

AU - Nalluri, Anusha

AU - Yang, Chuan Bin

AU - Wang, Ziying

AU - Sreenivasmurthy, Sravan Gopalkrishnashetty

AU - Zhu, Zhou

AU - Liu, Jia

AU - Su, Chengfu

AU - Krishnamoorthi, Senthilkumar

AU - Iyaswamy, Ashok

AU - Cheung, King Ho

AU - Lu, Jia Hong

AU - Li, Min

PY - 2020/2

Y1 - 2020/2

N2 - Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.

AB - Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.

KW - Aggregates

KW - Aggrephagy

KW - Alzheimer’s disease

KW - Selective autophagy

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U2 - 10.3390/cells9020311

DO - 10.3390/cells9020311

M3 - Review article

C2 - 32012902

AN - SCOPUS:85089725259

SN - 2073-4409

VL - 9

JO - Cells

JF - Cells

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M1 - 311

ER -

Targeting aggrephagy for the treatment of Alzheimer’s disease

Abstract

Keywords

ASJC Scopus subject areas

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