Tachykinin receptors as drug targets for motility disorders

Willemijntje A. Hoogerwerf; Sushil K. Sarna

doi:10.1159/000090311

Tachykinin receptors as drug targets for motility disorders

Willemijntje A. Hoogerwerf, Sushil K. Sarna

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.

Original language	English (US)
Pages (from-to)	83-90
Number of pages	8
Journal	Digestive Diseases
Volume	24
Issue number	1-2
DOIs	https://doi.org/10.1159/000090311
State	Published - May 2006

Keywords

Gastrointestinal motility
Inflammatory bowel disease
Irritable bowel syndrome
Prokinetics agents
Tachykinins

ASJC Scopus subject areas

Gastroenterology

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10.1159/000090311

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title = "Tachykinin receptors as drug targets for motility disorders",

abstract = "The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.",

keywords = "Gastrointestinal motility, Inflammatory bowel disease, Irritable bowel syndrome, Prokinetics agents, Tachykinins",

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AU - Sarna, Sushil K.

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N2 - The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.

AB - The tachykinins and their receptors are strategically distributed within the gut wall, spinal cord, and central nervous system to be potential targets of therapeutic agents for gastrointestinal motility disorders. However, the development of effective tachykinin receptor agonists or antagonists to treat these disorders has had very limited success so far. This is, in part, due to the complex and multilevel of regulation of gastrointestinal motility function and the challenges faced in targeting the specific type of gut contraction to normalize function in disease state.

KW - Gastrointestinal motility

KW - Inflammatory bowel disease

KW - Irritable bowel syndrome

KW - Prokinetics agents

KW - Tachykinins

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Tachykinin receptors as drug targets for motility disorders

Abstract

Keywords

ASJC Scopus subject areas

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