TY - JOUR
T1 - T helper type 1 cells in asthma
T2 - Friend or foe?
AU - Stephens, Robin
AU - Eisenbarth, Stephanie C.
AU - Chaplin, David D.
PY - 2002
Y1 - 2002
N2 - A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored.
AB - A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored.
UR - http://www.scopus.com/inward/record.url?scp=0036205793&partnerID=8YFLogxK
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U2 - 10.1097/00130832-200202000-00006
DO - 10.1097/00130832-200202000-00006
M3 - Review article
C2 - 11964748
AN - SCOPUS:0036205793
SN - 1528-4050
VL - 2
SP - 31
EP - 37
JO - Current opinion in allergy and clinical immunology
JF - Current opinion in allergy and clinical immunology
IS - 1
ER -