T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor α, β, or γ genes

Jeffrey M. Leiden, Keith M. Gottesdiener, Thomas Quertermous, Larry Coury, Robert A. Bray, Lisa Gottschalk, Howard Gebel, Jon G. Seidman, Jack L. Strominger, Alan L. Landay, Jacki Kornbluth

Research output: Contribution to journalArticlepeer-review

Abstract

To test the hypothesis that the T-cell receptor (Tcr) λ gene encodes a natural killer (NK) cell receptor molecule, three human NK clones and fresh peripheral blood lymphocytes with NK activity from two patients with a CD16+ lymphocytosis were analyzed for rearrangements and expression of the human Tcr α, β, and λ genes. Two of the clones displayed distinct rearrangements of their Tcr β and λ genes and expressed mature Tcr α, β, and αl RNA. However, one of the clones and both patient samples displayed marked NK activity but failed to rearrange or express any of their Tcr genes. These findings demonstrate that human natural killer activity is not dependent on Tcr λ gene rearrangement and expression. In addition, they confirm previous findings concerning the lack of Tcr α and β gene expression in some natural killer cells. Thus, they suggest the existence of additional NK-specific recognition molecules.

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
JournalImmunogenetics
Volume27
Issue number4
DOIs
StatePublished - Apr 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Genetics

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