Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2′-deosyuridine at Defined Sites

Lawrence C. Sowers; G. Peter Beardsley

doi:10.1021/jo00059a011

Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2′-deosyuridine at Defined Sites

Lawrence C. Sowers, G. Peter Beardsley

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2′-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.

Original language	English (US)
Pages (from-to)	1664-1665
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	58
Issue number	7
DOIs	https://doi.org/10.1021/jo00059a011
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00059a011

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@article{1ca4793cda6d4180a99e2695fe09a65b,

title = "Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2′-deosyuridine at Defined Sites",

abstract = "A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2′-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.",

author = "Sowers, {Lawrence C.} and Beardsley, {G. Peter}",

year = "1993",

doi = "10.1021/jo00059a011",

language = "English (US)",

volume = "58",

pages = "1664--1665",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "7",

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T1 - Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2′-deosyuridine at Defined Sites

AU - Sowers, Lawrence C.

AU - Beardsley, G. Peter

PY - 1993

Y1 - 1993

N2 - A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2′-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.

AB - A method is described for the solid-phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-(hydroxymethyl)-2′-deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-(hydroxymethyl) group.

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U2 - 10.1021/jo00059a011

DO - 10.1021/jo00059a011

M3 - Article

AN - SCOPUS:0027243510

SN - 0022-3263

VL - 58

SP - 1664

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 7

ER -

Synthesis of Oligonucleotides Containing 5-(Hydroxymethyl)-2′-deosyuridine at Defined Sites

Abstract

ASJC Scopus subject areas

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