Synthesis and properties of novel nitrogen mustard linked phosphoryl diamide derivatives

Ru Yu Chen; Li Juan Mao; Hui Lin Wang; Jia Zhou

doi:10.1080/10426509408020437

Synthesis and properties of novel nitrogen mustard linked phosphoryl diamide derivatives

Ru Yu Chen, Li Juan Mao, Hui Lin Wang, Jia Zhou

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).

Original language	English (US)
Pages (from-to)	89-95
Number of pages	7
Journal	Phosphorus, Sulfur, and Silicon and the Related Elements
Volume	89
Issue number	1-4
DOIs	https://doi.org/10.1080/10426509408020437
State	Published - Apr 1 1994
Externally published	Yes

Keywords

Antitumor
antivirus
nitrogen mustard
phosphoryl diamide

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Inorganic Chemistry

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10.1080/10426509408020437

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title = "Synthesis and properties of novel nitrogen mustard linked phosphoryl diamide derivatives",

abstract = "Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).",

keywords = "Antitumor, antivirus, nitrogen mustard, phosphoryl diamide",

author = "Chen, {Ru Yu} and Mao, {Li Juan} and Wang, {Hui Lin} and Jia Zhou",

note = "Funding Information: This project was supported by the National Natural Science Foundation of China.",

year = "1994",

month = apr,

day = "1",

doi = "10.1080/10426509408020437",

language = "English (US)",

volume = "89",

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journal = "Phosphorus, Sulfur, and Silicon and the Related Elements",

issn = "1042-6507",

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TY - JOUR

T1 - Synthesis and properties of novel nitrogen mustard linked phosphoryl diamide derivatives

AU - Chen, Ru Yu

AU - Mao, Li Juan

AU - Wang, Hui Lin

AU - Zhou, Jia

N1 - Funding Information: This project was supported by the National Natural Science Foundation of China.

PY - 1994/4/1

Y1 - 1994/4/1

N2 - Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).

AB - Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).

KW - Antitumor

KW - antivirus

KW - nitrogen mustard

KW - phosphoryl diamide

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DO - 10.1080/10426509408020437

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VL - 89

SP - 89

EP - 95

JO - Phosphorus, Sulfur, and Silicon and the Related Elements

JF - Phosphorus, Sulfur, and Silicon and the Related Elements

IS - 1-4

ER -

Synthesis and properties of novel nitrogen mustard linked phosphoryl diamide derivatives

Abstract

Keywords

ASJC Scopus subject areas

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