Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Matthew J. Panzner; Arpaporn Deeraksa; Alyssa Smith; Brian D. Wright; Khadijah M. Hindi; Aysegul Kascatan-Nebioglu; Alfredo G. Torres; Barbara M. Judy; Christine E. Hovis; Julia K. Hilliard; Rebekah J. Mallett; Emily Cope; D. Mark Estes; Carolyn L. Cannon; Jeff G. Leid; Wiley J. Youngs

doi:10.1002/ejic.200801159

Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Matthew J. Panzner, Arpaporn Deeraksa, Alyssa Smith, Brian D. Wright, Khadijah M. Hindi, Aysegul Kascatan-Nebioglu, Alfredo G. Torres, Barbara M. Judy, Christine E. Hovis, Julia K. Hilliard, Rebekah J. Mallett, Emily Cope, D. Mark Estes, Carolyn L. Cannon, Jeff G. Leid, Wiley J. Youngs

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

Original language	English (US)
Pages (from-to)	1739-1745
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Issue number	13 SPEC. ISS.
DOIs	https://doi.org/10.1002/ejic.200801159
State	Published - May 2009

Keywords

Antibiotics
Burkholderia
Carbenes
N-Heterocyclic carbenes
Nitrogen heterocycles
Silver

ASJC Scopus subject areas

Inorganic Chemistry

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Panzner, M. J., Deeraksa, A., Smith, A., Wright, B. D., Hindi, K. M., Kascatan-Nebioglu, A., Torres, A. G., Judy, B. M., Hovis, C. E., Hilliard, J. K., Mallett, R. J., Cope, E., Estes, D. M., Cannon, C. L., Leid, J. G., & Youngs, W. J. (2009). Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria. European Journal of Inorganic Chemistry, (13 SPEC. ISS.), 1739-1745. https://doi.org/10.1002/ejic.200801159

Panzner, MJ, Deeraksa, A, Smith, A, Wright, BD, Hindi, KM, Kascatan-Nebioglu, A, Torres, AG, Judy, BM, Hovis, CE, Hilliard, JK, Mallett, RJ, Cope, E, Estes, DM, Cannon, CL, Leid, JG & Youngs, WJ 2009, 'Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria', European Journal of Inorganic Chemistry, no. 13 SPEC. ISS., pp. 1739-1745. https://doi.org/10.1002/ejic.200801159

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abstract = "A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.",

keywords = "Antibiotics, Burkholderia, Carbenes, N-Heterocyclic carbenes, Nitrogen heterocycles, Silver",

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AU - Panzner, Matthew J.

AU - Deeraksa, Arpaporn

AU - Smith, Alyssa

AU - Wright, Brian D.

AU - Hindi, Khadijah M.

AU - Kascatan-Nebioglu, Aysegul

AU - Torres, Alfredo G.

AU - Judy, Barbara M.

AU - Hovis, Christine E.

AU - Hilliard, Julia K.

AU - Mallett, Rebekah J.

AU - Cope, Emily

AU - Estes, D. Mark

AU - Cannon, Carolyn L.

AU - Leid, Jeff G.

AU - Youngs, Wiley J.

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AB - A series of N-heterocyclic carbene silver complexes havebeen synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burk-holderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assaysdemonstrated the exceptional efficacy of the complexesagainst these potentially weaponizable pathogens.

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KW - Burkholderia

KW - Carbenes

KW - N-Heterocyclic carbenes

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Synthesis and in vitro efficacy studies of silver carbene complexes on biosafety level 3 bacteria

Abstract

Keywords

ASJC Scopus subject areas

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