Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki; Bhesh Raj Sharma; Shraddha Tuladhar; Evan Peter Williams; Lillian Zalduondo; Parimal Samir; Min Zheng; Balamurugan Sundaram; Balaji Banoth; R. K.Subbarao Malireddi; Patrick Schreiner; Geoffrey Neale; Peter Vogel; Richard Webby; Colleen Beth Jonsson; Thirumala Devi Kanneganti

doi:10.1016/j.cell.2020.11.025

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R. K.Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala Devi Kanneganti

Research output: Contribution to journal › Article › peer-review

Abstract

TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

Original language	English (US)
Pages (from-to)	149-168.e17
Journal	Cell
Volume	184
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2020.11.025
State	Published - Jan 7 2021
Externally published	Yes

Keywords

COVID-19
IFN-γ
PANoptosis
SARS-CoV-2
TNF-α
apoptosis
cytokine storm
inflammation
necroptosis
pyroptosis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2020.11.025

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Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., Schreiner, P., Neale, G., Vogel, P., Webby, R., Jonsson, C. B., & Kanneganti, T. D. (2021). Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell, 184(1), 149-168.e17. https://doi.org/10.1016/j.cell.2020.11.025

Karki, R, Sharma, BR, Tuladhar, S, Williams, EP, Zalduondo, L, Samir, P, Zheng, M, Sundaram, B, Banoth, B, Malireddi, RKS, Schreiner, P, Neale, G, Vogel, P, Webby, R, Jonsson, CB & Kanneganti, TD 2021, 'Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes', Cell, vol. 184, no. 1, pp. 149-168.e17. https://doi.org/10.1016/j.cell.2020.11.025

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title = "Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes",

abstract = "TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.",

keywords = "COVID-19, IFN-γ, PANoptosis, SARS-CoV-2, TNF-α, apoptosis, cytokine storm, inflammation, necroptosis, pyroptosis",

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doi = "10.1016/j.cell.2020.11.025",

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AU - Karki, Rajendra

AU - Sharma, Bhesh Raj

AU - Tuladhar, Shraddha

AU - Williams, Evan Peter

AU - Zalduondo, Lillian

AU - Samir, Parimal

AU - Zheng, Min

AU - Sundaram, Balamurugan

AU - Banoth, Balaji

AU - Malireddi, R. K.Subbarao

AU - Schreiner, Patrick

AU - Neale, Geoffrey

AU - Vogel, Peter

AU - Webby, Richard

AU - Jonsson, Colleen Beth

AU - Kanneganti, Thirumala Devi

PY - 2021/1/7

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AB - TNF-α and IFN-γ synergize to drive the cytokine storm and cell death associated with COVID-19 and sepsis.

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KW - IFN-γ

KW - PANoptosis

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KW - TNF-α

KW - apoptosis

KW - cytokine storm

KW - inflammation

KW - necroptosis

KW - pyroptosis

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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Abstract

Keywords

ASJC Scopus subject areas

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