Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes

Subhamoy Das; Anthony J. Monteforte; Gunjan Singh; Marjan Majid; Michael B. Sherman; Andrew K. Dunn; Aaron B. Baker

doi:10.1002/adhm.201500993

Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes

Subhamoy Das, Anthony J. Monteforte, Gunjan Singh, Marjan Majid, Michael B. Sherman, Andrew K. Dunn, Aaron B. Baker

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.

Original language	English (US)
Pages (from-to)	1008-1013
Number of pages	6
Journal	Advanced Healthcare Materials
Volume	5
Issue number	9
DOIs	https://doi.org/10.1002/adhm.201500993
State	Published - May 11 2016

Keywords

Fibroblast growth factor-2 (FGF-2)
Ischemia
Peripheral vascular diseases
Syndecan-4
Therapeutic angiogenesis

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.201500993

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title = "Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes",

abstract = "Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.",

keywords = "Fibroblast growth factor-2 (FGF-2), Ischemia, Peripheral vascular diseases, Syndecan-4, Therapeutic angiogenesis",

author = "Subhamoy Das and Monteforte, {Anthony J.} and Gunjan Singh and Marjan Majid and Sherman, {Michael B.} and Dunn, {Andrew K.} and Baker, {Aaron B.}",

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doi = "10.1002/adhm.201500993",

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AU - Das, Subhamoy

AU - Monteforte, Anthony J.

AU - Singh, Gunjan

AU - Majid, Marjan

AU - Sherman, Michael B.

AU - Dunn, Andrew K.

AU - Baker, Aaron B.

PY - 2016/5/11

Y1 - 2016/5/11

N2 - Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.

AB - Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype.

KW - Fibroblast growth factor-2 (FGF-2)

KW - Ischemia

KW - Peripheral vascular diseases

KW - Syndecan-4

KW - Therapeutic angiogenesis

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Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes

Abstract

Keywords

ASJC Scopus subject areas

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