suPAR, a Circulating Kidney Disease Factor

Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser

Research output: Contribution to journalReview articlepeer-review

Abstract

Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.

Original languageEnglish (US)
Article number745838
JournalFrontiers in Medicine
Volume8
DOIs
StatePublished - Oct 6 2021
Externally publishedYes

Keywords

  • isoform
  • kidney
  • proteinuric disease
  • suPAR
  • uPAR

ASJC Scopus subject areas

  • General Medicine

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