1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy

Harshesh Bhatt; Maruthi Kashyap; Neel Sarovar Bhavesh

doi:10.1007/s12104-010-9229-6

¹H, ¹³C and ¹⁵N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy

Harshesh Bhatt, Maruthi Kashyap, Neel Sarovar Bhavesh

Research output: Contribution to journal › Article › peer-review

Abstract

BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca²⁺. Here, we report sequence-specific ¹H, ¹³C, and ¹⁵N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Biomolecular NMR Assignments
Volume	4
Issue number	2
DOIs	https://doi.org/10.1007/s12104-010-9229-6
State	Published - Oct 2010
Externally published	Yes

Keywords

Alternate splicing factor
BRUNOL-3
Cardiac troponin T
Myotonic dystrophy

ASJC Scopus subject areas

Structural Biology
Biochemistry

Access to Document

10.1007/s12104-010-9229-6

Cite this

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title = "1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy",

abstract = "BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca2+. Here, we report sequence-specific 1H, 13C, and 15N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.",

keywords = "Alternate splicing factor, BRUNOL-3, Cardiac troponin T, Myotonic dystrophy",

author = "Harshesh Bhatt and Maruthi Kashyap and Bhavesh, {Neel Sarovar}",

year = "2010",

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AU - Bhatt, Harshesh

AU - Kashyap, Maruthi

AU - Bhavesh, Neel Sarovar

PY - 2010/10

Y1 - 2010/10

N2 - BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca2+. Here, we report sequence-specific 1H, 13C, and 15N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.

AB - BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca2+. Here, we report sequence-specific 1H, 13C, and 15N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.

KW - Alternate splicing factor

KW - BRUNOL-3

KW - Cardiac troponin T

KW - Myotonic dystrophy

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