¹¹¹In chloride bone marrow scintigraphy and ferrokinetic studies in a case of sickle cell anemia with transient erythroid aplasia

A patient with sickle cell anemia was hospitalized because of an acute erythropoietic aplastic crisis.¹¹¹In chloride bone marrow scintigraphy performed during the aplastic crisis showed markedly impaired uptake of the radionuclide and simultaneous r,⁵⁹Fe clearance T1/2 studies were prolonged (420.9 min). Following recovery from the aplastic crisis¹¹¹In scintigraphy revealed an expanded marrow and the radioiron clearance T1/2, was accelerated (20.9 min). The clinical course, hemograms and bone marrow aspirations correlated with marrow scintigraphy.¹¹¹In appears to be a valuable bone marrow scanning agent for assessing the presence of intramedulllary erythropoietic activity.