@inbook{72b630714bce4ea79ddda6b2572d0f10,
title = "Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling",
abstract = "Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both outside of and within animal hosts. Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. These high-dimensional omics datasets are being integrated in selected ways to improve genome annotations, discover novel virulence-related factors, and model growth under infectious states. We will review the evolving technological approaches toward understanding complex microbial life through multi-omic measurements and integration, while highlighting some of our most recent successes in this area.",
author = "Charles Ansong and Deatherage, {Brooke L.} and Daniel Hyduke and Brian Schmidt and McDermott, {Jason E.} and Jones, {Marcus B.} and Sadhana Chauhan and Pep Charusanti and Kim, {Young Mo} and Nakayasu, {Ernesto S.} and Jie Li and Afshan Kidwai and George Niemann and Brown, {Roslyn N.} and Metz, {Thomas O.} and Kathleen McAteer and Fred Heffron and Peterson, {Scott N.} and Vladimir Motin and Palsson, {Bernhard O.} and Smith, {Richard D.} and Adkins, {Joshua N.}",
note = "Funding Information: Research described was supported by the National Institute of Allergy and Infectious Diseases NIH/DHHS through Interagency agreement Y1-AI-8401. Proteomics and metabolomics capabilities were developed under support from the US Department of Energy (DOE) Office of Biological and Environmental Research (BER) and the NIH grants 5P41RR018522-10 and the National Institute of General Medical Sciences grant (8 P41 GM103493-10), and work was performed in the Environmental Molecular Sciences Laboratory, a DOE-BER national scientific user facility at Pacific Northwest National Laboratory (PNNL). PNNL is a multiprogram national laboratory operated by Battelle Memorial Institute for the DOE under contract DE-AC05-76RLO 1830.",
year = "2012",
doi = "10.1007/82-2012-247",
language = "English (US)",
isbn = "9783642330988",
series = "Current Topics in Microbiology and Immunology",
pages = "21--41",
editor = "Katze, {Michael G.}",
booktitle = "Systems Biology",
}