Structure and morphogenesis of bacteriophage T4

P. G. Leiman; S. Kanamaru; V. V. Mesyanzhinov; F. Arisaka; M. G. Rossmann

doi:10.1007/s00018-003-3072-1

Structure and morphogenesis of bacteriophage T4

P. G. Leiman, S. Kanamaru, V. V. Mesyanzhinov, F. Arisaka, M. G. Rossmann

Research output: Contribution to journal › Review article › peer-review

179 Scopus citations

Abstract

Bacteriophage T4 is one of the most complex viruses. More than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a 'tail,' and fibers, attached to the distal end of the tail. The fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. The tail also serves as a channel for delivery of the phage DNA from the head into the host cell cytoplasm. The tail is attached to the unique 'portal' vertex of the head through which the phage DNA is packaged during head assembly. Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging.

Original language	English (US)
Pages (from-to)	2356-2370
Number of pages	15
Journal	Cellular and Molecular Life Sciences
Volume	60
Issue number	11
DOIs	https://doi.org/10.1007/s00018-003-3072-1
State	Published - Nov 2003
Externally published	Yes

Keywords

Bacteriophage T4
Baseplate
Contractile tail
DNA packaging
Fibrous protein
Phage infection
Prolate head capsid

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s00018-003-3072-1

Cite this

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abstract = "Bacteriophage T4 is one of the most complex viruses. More than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a 'tail,' and fibers, attached to the distal end of the tail. The fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. The tail also serves as a channel for delivery of the phage DNA from the head into the host cell cytoplasm. The tail is attached to the unique 'portal' vertex of the head through which the phage DNA is packaged during head assembly. Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging.",

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AU - Kanamaru, S.

AU - Mesyanzhinov, V. V.

AU - Arisaka, F.

AU - Rossmann, M. G.

PY - 2003/11

Y1 - 2003/11

N2 - Bacteriophage T4 is one of the most complex viruses. More than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a 'tail,' and fibers, attached to the distal end of the tail. The fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. The tail also serves as a channel for delivery of the phage DNA from the head into the host cell cytoplasm. The tail is attached to the unique 'portal' vertex of the head through which the phage DNA is packaged during head assembly. Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging.

AB - Bacteriophage T4 is one of the most complex viruses. More than 40 different proteins form the mature virion, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a 'tail,' and fibers, attached to the distal end of the tail. The fibers and the tail carry the host cell recognition sensors and are required for attachment of the phage to the cell surface. The tail also serves as a channel for delivery of the phage DNA from the head into the host cell cytoplasm. The tail is attached to the unique 'portal' vertex of the head through which the phage DNA is packaged during head assembly. Similar to other phages, and also herpes viruses, the unique vertex is occupied by a dodecameric portal protein, which is involved in DNA packaging.

KW - Bacteriophage T4

KW - Baseplate

KW - Contractile tail

KW - DNA packaging

KW - Fibrous protein

KW - Phage infection

KW - Prolate head capsid

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Structure and morphogenesis of bacteriophage T4

Abstract

Keywords

ASJC Scopus subject areas

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