Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

Alan P. Kozikowski; Marinella Roberti; Xiang Li Xiang; John S. Bergmann; Patrick M. Callahan; Kathryn A. Cunningham; Kenneth M. Johnson

doi:10.1021/jm00103a015

Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

Alan P. Kozikowski, Marinella Roberti, Xiang Li Xiang, John S. Bergmann, Patrick M. Callahan, Kathryn A. Cunningham, Kenneth M. Johnson

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Original language	English (US)
Pages (from-to)	4764-4766
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	35
Issue number	25
DOIs	https://doi.org/10.1021/jm00103a015
State	Published - Dec 1 1992

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm00103a015

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Kozikowski, A. P., Roberti, M., Li Xiang, X., Bergmann, J. S., Callahan, P. M., Cunningham, K. A., & Johnson, K. M. (1992). Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. Journal of medicinal chemistry, 35(25), 4764-4766. https://doi.org/10.1021/jm00103a015

Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue. / Kozikowski, Alan P.; Roberti, Marinella; Li Xiang, Xiang et al.
In: Journal of medicinal chemistry, Vol. 35, No. 25, 01.12.1992, p. 4764-4766.

Research output: Contribution to journal › Article › peer-review

Kozikowski, AP, Roberti, M, Li Xiang, X, Bergmann, JS, Callahan, PM, Cunningham, KA & Johnson, KM 1992, 'Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue', Journal of medicinal chemistry, vol. 35, no. 25, pp. 4764-4766. https://doi.org/10.1021/jm00103a015

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Structure-Activity Relationship Studies of Cocaine: Replacement of the C-2 Ester Group by Vinyl Argues against H-Bonding and Provides an Esterase-Resistant, High-Affinity Cocaine Analogue

ASJC Scopus subject areas

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