Structural insights into the architecture of the hyperthermophilic fusellovirus SSV1

Kenneth M. Stedman; Melissa DeYoung; Mitul Saha; Michael B. Sherman; Marc C. Morais

doi:10.1016/j.virol.2014.10.014

Structural insights into the architecture of the hyperthermophilic fusellovirus SSV1

Kenneth M. Stedman, Melissa DeYoung, Mitul Saha, Michael B. Sherman, Marc C. Morais

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.

Original language	English (US)
Pages (from-to)	105-109
Number of pages	5
Journal	Virology
Volume	474
DOIs	https://doi.org/10.1016/j.virol.2014.10.014
State	Published - Jan 1 2015

Keywords

Archaeal virus
Extremophile
Fullerene cone
Fusellovirus
Hyperthermophilic virus
SSV
SSV1
Spindle-shaped virus
Virus assembly
Virus structure

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2014.10.014

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title = "Structural insights into the architecture of the hyperthermophilic fusellovirus SSV1",

abstract = "The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.",

keywords = "Archaeal virus, Extremophile, Fullerene cone, Fusellovirus, Hyperthermophilic virus, SSV, SSV1, Spindle-shaped virus, Virus assembly, Virus structure",

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AU - Stedman, Kenneth M.

AU - DeYoung, Melissa

AU - Saha, Mitul

AU - Sherman, Michael B.

AU - Morais, Marc C.

PY - 2015/1/1

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AB - The structure and assembly of many icosahedral and helical viruses are well-characterized. However, the molecular basis for the unique spindle-shaped morphology of many viruses that infect Archaea remains unknown. To understand the architecture and assembly of these viruses, the spindle-shaped virus SSV1 was examined using cryo-EM, providing the first 3D-structure of a spindle-shaped virus as well as insight into SSV1 biology, assembly and evolution. Furthermore, a geometric framework underlying the distinct spindle-shaped structure is proposed.

KW - Archaeal virus

KW - Extremophile

KW - Fullerene cone

KW - Fusellovirus

KW - Hyperthermophilic virus

KW - SSV

KW - SSV1

KW - Spindle-shaped virus

KW - Virus assembly

KW - Virus structure

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Structural insights into the architecture of the hyperthermophilic fusellovirus SSV1

Abstract

Keywords

ASJC Scopus subject areas

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