Structural basis of selective inhibition of human tankyrases

INIS

• humans 100%
• crystal structure 100%
• inhibition 100%
• adp 66%
• nicotinamide 66%
• proteins 33%
• cancer 33%
• enzymes 33%
• data 33%
• homeostasis 33%
• substrates 33%
• conformational changes 33%
• polymerases 33%
• structure-activity relationships 33%
• telomeres 33%
• flexibility 33%
• ribose 33%

Biochemistry, Genetics and Molecular Biology

• Poly ADP Ribose Polymerase 100%
• Crystal Structure 75%
• Nicotinamide 50%
• Protein 25%
• Development 25%
• Enzyme 25%
• Conformational Change 25%
• Telomere Homeostasis 25%
• Binding Site 25%
• Wnt Signaling Pathway 25%
• Cell Function 25%
• Structure Activity Relation 25%

Keyphrases

• IWR-1 33%
• PARP2 16%
• Existing Structures 16%
• Substrate Binding Loop 16%
• Telomere Homeostasis 16%