Stimulatory effects of immunoreactive-growth hormone on proliferation of a human lymphocyte cell line

T. L. Kao; W. J. Meyer

doi:10.1016/0304-3835(94)90158-9

Stimulatory effects of immunoreactive-growth hormone on proliferation of a human lymphocyte cell line

T. L. Kao, W. J. Meyer

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Previous studies have indicated the secretion of a growth hormone-like molecule by the lymphocyte T-cell line, H9. We examined the autocrine growth-promoting effects of this T-cell derived factor. H9 conditioned medium stimulates proliferation of H9 cells themselves in a dose-dependent fashion. This growth stimulating effect could be blocked by anti-human growth hormone antiserum, but could not be simulated by addition of growth hormone only or interleukin 2 only, or a combination of both. Dexamethasone inhibited H9 growth in low nutrient culture conditions and seemed to somewhat offset the growth promoting effect of the hGH-like molecule. However, the exact role played by dexamethasone in H9 cell growth and death, as well as the exact mechanism by which the hGH-like molecule exerted its growth-promoting action, remain to be elucidated.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Cancer Letters
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)90158-9
State	Published - Jun 15 1994
Externally published	Yes

Keywords

Dexamethasone
Growth
Growth hormone
Lymphocyte

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(94)90158-9

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title = "Stimulatory effects of immunoreactive-growth hormone on proliferation of a human lymphocyte cell line",

abstract = "Previous studies have indicated the secretion of a growth hormone-like molecule by the lymphocyte T-cell line, H9. We examined the autocrine growth-promoting effects of this T-cell derived factor. H9 conditioned medium stimulates proliferation of H9 cells themselves in a dose-dependent fashion. This growth stimulating effect could be blocked by anti-human growth hormone antiserum, but could not be simulated by addition of growth hormone only or interleukin 2 only, or a combination of both. Dexamethasone inhibited H9 growth in low nutrient culture conditions and seemed to somewhat offset the growth promoting effect of the hGH-like molecule. However, the exact role played by dexamethasone in H9 cell growth and death, as well as the exact mechanism by which the hGH-like molecule exerted its growth-promoting action, remain to be elucidated.",

keywords = "Dexamethasone, Growth, Growth hormone, Lymphocyte",

author = "Kao, {T. L.} and Meyer, {W. J.}",

note = "Funding Information: This work was partially supported by the George and Mary Josephine Hamman Grant and the James W. McLaughlin Fellowship Fund. The authors wish to thank Nita Brannon for preparing the manuscript.",

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AU - Kao, T. L.

AU - Meyer, W. J.

N1 - Funding Information: This work was partially supported by the George and Mary Josephine Hamman Grant and the James W. McLaughlin Fellowship Fund. The authors wish to thank Nita Brannon for preparing the manuscript.

PY - 1994/6/15

Y1 - 1994/6/15

N2 - Previous studies have indicated the secretion of a growth hormone-like molecule by the lymphocyte T-cell line, H9. We examined the autocrine growth-promoting effects of this T-cell derived factor. H9 conditioned medium stimulates proliferation of H9 cells themselves in a dose-dependent fashion. This growth stimulating effect could be blocked by anti-human growth hormone antiserum, but could not be simulated by addition of growth hormone only or interleukin 2 only, or a combination of both. Dexamethasone inhibited H9 growth in low nutrient culture conditions and seemed to somewhat offset the growth promoting effect of the hGH-like molecule. However, the exact role played by dexamethasone in H9 cell growth and death, as well as the exact mechanism by which the hGH-like molecule exerted its growth-promoting action, remain to be elucidated.

AB - Previous studies have indicated the secretion of a growth hormone-like molecule by the lymphocyte T-cell line, H9. We examined the autocrine growth-promoting effects of this T-cell derived factor. H9 conditioned medium stimulates proliferation of H9 cells themselves in a dose-dependent fashion. This growth stimulating effect could be blocked by anti-human growth hormone antiserum, but could not be simulated by addition of growth hormone only or interleukin 2 only, or a combination of both. Dexamethasone inhibited H9 growth in low nutrient culture conditions and seemed to somewhat offset the growth promoting effect of the hGH-like molecule. However, the exact role played by dexamethasone in H9 cell growth and death, as well as the exact mechanism by which the hGH-like molecule exerted its growth-promoting action, remain to be elucidated.

KW - Dexamethasone

KW - Growth

KW - Growth hormone

KW - Lymphocyte

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Stimulatory effects of immunoreactive-growth hormone on proliferation of a human lymphocyte cell line

Abstract

Keywords

ASJC Scopus subject areas

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