TY - JOUR
T1 - Still SDAPing Along
T2 - 20 Years of the Structural Database of Allergenic Proteins
AU - Schein, Catherine H.
AU - Negi, Surendra S.
AU - Braun, Werner
N1 - Publisher Copyright:
Copyright © 2022 Schein, Negi and Braun.
PY - 2022
Y1 - 2022
N2 - The introduction of plant extracts to mitigate the symptoms of “hay fever”, about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins were cloned, there was a need to rapidly identify and categorize those with significant similarity to known allergens. The Structural Database of Allergenic Proteins (SDAP) was created at the beginning of the 21st century as the first cross-referenced website to allow rapid overview of the structures and sequences of allergenic proteins. SDAP provides a way to identify sequence and functional similarities between these proteins, despite the complex nomenclature system based on the Latin names of their different sources. A rapid FASTA search simplifies grouping allergens from the same structural or functional family. SDAP also provides an overview of the rapidly expanding literature on the sequence, structure and epitopes of allergenic proteins and a way to estimate the potential allergenicity of novel proteins based on rules provided by the IUIS. Twenty years and a pandemic later, the list of allergenic proteins and their attributes continues to grow. SDAP is expanding and improving to allow rapid access to all this information.
AB - The introduction of plant extracts to mitigate the symptoms of “hay fever”, about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins were cloned, there was a need to rapidly identify and categorize those with significant similarity to known allergens. The Structural Database of Allergenic Proteins (SDAP) was created at the beginning of the 21st century as the first cross-referenced website to allow rapid overview of the structures and sequences of allergenic proteins. SDAP provides a way to identify sequence and functional similarities between these proteins, despite the complex nomenclature system based on the Latin names of their different sources. A rapid FASTA search simplifies grouping allergens from the same structural or functional family. SDAP also provides an overview of the rapidly expanding literature on the sequence, structure and epitopes of allergenic proteins and a way to estimate the potential allergenicity of novel proteins based on rules provided by the IUIS. Twenty years and a pandemic later, the list of allergenic proteins and their attributes continues to grow. SDAP is expanding and improving to allow rapid access to all this information.
KW - IgE epitopes
KW - allergenic protein nomenclature
KW - component resolved extracts
KW - history of allergen studies
KW - peanut and nut allergens
KW - physicochemical property scale
KW - property distance scale
KW - sequence and structure
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U2 - 10.3389/falgy.2022.863172
DO - 10.3389/falgy.2022.863172
M3 - Article
AN - SCOPUS:85159926771
SN - 2673-6101
VL - 3
JO - Frontiers in Allergy
JF - Frontiers in Allergy
M1 - 863172
ER -