TY - GEN
T1 - Statins for the treatment of antiphospholipid syndrome
AU - Jajoria, Praveen
AU - Murthy, Vijaya
AU - Papalardo, Elizabeth
AU - Romay-Penabad, Zurina
AU - Gleason, Caroline
AU - Pierangeli, Silvia S.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2009/9
Y1 - 2009/9
N2 - Fluvastatin has been shown to revert proinflammatoryprothrombotic effects of antiphospholipid antibodies (aPL) in vitro and in mice. Here, we examined whether fluvastatin affects the levels of proinflammatoryprothrombotic markers in antiphospholipid syndrome (APS) patients. Vascular endothelial growth factor (VEGF), soluble tissue factor (sTF), tumor necrosis factor-α (TNF-α), soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin (E-sel), C-reactive protein (CRP), and soluble vascular cell adhesion molecule (sVCAM-1), were measured in the sera of 93 APS patients and 60 controls and in the sera of nine patients with APS before and after 30 days of treatment with fluvastatin. Elevated levels of VEGF, sTF, and TNF-α were found in APS patients. Fluvastatin significantly reduced those markers in the majority of treated subjects. The data from this study show that statins may be beneficial in aPL-positive patients and warrant larger clinical trials to confirm the efficacy of the drug for the treatment of APS clinical manifestations.
AB - Fluvastatin has been shown to revert proinflammatoryprothrombotic effects of antiphospholipid antibodies (aPL) in vitro and in mice. Here, we examined whether fluvastatin affects the levels of proinflammatoryprothrombotic markers in antiphospholipid syndrome (APS) patients. Vascular endothelial growth factor (VEGF), soluble tissue factor (sTF), tumor necrosis factor-α (TNF-α), soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin (E-sel), C-reactive protein (CRP), and soluble vascular cell adhesion molecule (sVCAM-1), were measured in the sera of 93 APS patients and 60 controls and in the sera of nine patients with APS before and after 30 days of treatment with fluvastatin. Elevated levels of VEGF, sTF, and TNF-α were found in APS patients. Fluvastatin significantly reduced those markers in the majority of treated subjects. The data from this study show that statins may be beneficial in aPL-positive patients and warrant larger clinical trials to confirm the efficacy of the drug for the treatment of APS clinical manifestations.
KW - Anticardiolipin antibodies
KW - Antiphospholipid antibodies
KW - Antiphospholipid syndrome
KW - Proinflammatory markers
KW - Statins
UR - http://www.scopus.com/inward/record.url?scp=70049117028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70049117028&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04815.x
DO - 10.1111/j.1749-6632.2009.04815.x
M3 - Conference contribution
C2 - 19758223
AN - SCOPUS:70049117028
SN - 9781573317627
T3 - Annals of the New York Academy of Sciences
SP - 736
EP - 745
BT - Contemporary Challenges in Autoimmunity
PB - Blackwell Publishing Inc.
ER -