Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy

Helena A. Lekan; Susan M. Carlton; Richard E. Coggeshall

doi:10.1016/0304-3940(96)12566-0

Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy

Helena A. Lekan, Susan M. Carlton, Richard E. Coggeshall

Neuroscience & Cell

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Cholera toxin β-subunit conjugated to horseradish peroxidase was used to label the large myelinated (Aβ) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, Aβ fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of Aβ input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Neuroscience Letters
Volume	208
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(96)12566-0
State	Published - Apr 26 1996

Keywords

Nociception
Plasticity
Primary afferents
Spinal cord

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(96)12566-0

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title = "Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy",

abstract = "Cholera toxin β-subunit conjugated to horseradish peroxidase was used to label the large myelinated (Aβ) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, Aβ fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of Aβ input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.",

keywords = "Nociception, Plasticity, Primary afferents, Spinal cord",

author = "Lekan, {Helena A.} and Carlton, {Susan M.} and Coggeshall, {Richard E.}",

note = "Funding Information: The authors wish to thank Gregory Hargett, Gena Krannig and Dr. Maria C. Barnes for their assistance with this study, and Brenda Kenworthy for preparing the manuscript. This work was supported by NIH grants NS 07185 (H.A.L.), NS 101.61 (R.E.C.), NS 11255 and NS 27910 (S.M.C.).",

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T1 - Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy

AU - Lekan, Helena A.

AU - Carlton, Susan M.

AU - Coggeshall, Richard E.

N1 - Funding Information: The authors wish to thank Gregory Hargett, Gena Krannig and Dr. Maria C. Barnes for their assistance with this study, and Brenda Kenworthy for preparing the manuscript. This work was supported by NIH grants NS 07185 (H.A.L.), NS 101.61 (R.E.C.), NS 11255 and NS 27910 (S.M.C.).

PY - 1996/4/26

Y1 - 1996/4/26

N2 - Cholera toxin β-subunit conjugated to horseradish peroxidase was used to label the large myelinated (Aβ) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, Aβ fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of Aβ input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.

AB - Cholera toxin β-subunit conjugated to horseradish peroxidase was used to label the large myelinated (Aβ) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, Aβ fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of Aβ input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.

KW - Nociception

KW - Plasticity

KW - Primary afferents

KW - Spinal cord

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Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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