Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host

Keyphrases

• Promastigote 100%
• Leishmania 100%
• Mammalian Host 100%
• Leishmania Major 100%
• Acidic pH 100%
• Sphingolipids 100%
• Nitrosative Stress 66%
• Immunodeficient Mice 66%
• Elevated Temperature 66%
• Nitric Oxide 33%
• Murine Macrophages 33%
• Immune Response 33%
• T Cell Response 33%
• Virulence 33%
• Interleukin-12 (IL-12) 33%
• Infected Mice 33%
• Host Cell 33%
• Sand Fly 33%
• Amastigote 33%
• Cell Activation 33%
• L. Major 33%
• Serious Diseases 33%
• Phagocytes 33%
• Adverse Conditions 33%
• Evade 33%
• Leishmania Infection 33%
• Leishmania Parasites 33%
• Macrophage Activation 33%
• Acidification 33%
• Acidic Environment 33%
• Harsh Conditions 33%
• Stationary Phase 33%
• Phagolysosome 33%
• Sphingolipid Metabolism 33%

Immunology and Microbiology

• Host 100%
• pH 100%
• Mutant 100%
• Leishmania 100%
• Leishmania Major 100%
• Mouse 60%
• Promastigote 60%
• Parasite 60%
• Nitrosative Stress 40%
• Wild Type 40%
• Temperature 40%
• T Cell 20%
• Macrophage 20%
• Immunity 20%
• Immune Response 20%
• Spectrum 20%
• Aptitude 20%
• Virulence 20%
• Host Cell 20%
• Phlebotominae 20%
• Amastigote 20%
• Cell Activation 20%
• Survival 20%
• Murine 20%
• Macrophage Activation 20%
• Phagocyte 20%
• Mammal 20%
• Interleukin 12 20%
• Acidification 20%
• Phagolysosome 20%
• Sphingolipid Metabolism 20%

INIS

• mutants 100%
• host 100%
• ph value 100%
• mice 60%
• parasites 60%
• oxidation 40%
• macrophages 40%
• production 20%
• diseases 20%
• metabolism 20%
• levels 20%
• pathology 20%
• nitric oxide 20%
• environment 20%
• interleukins 20%
• immunity 20%
• suppression 20%
• spectra 20%
• virulence 20%
• inhibition 20%
• mammals 20%
• flies 20%
• sand 20%
• resist 20%
• phagocytes 20%
• acidification 20%