Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara, Yaakov Levy

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

Original languageEnglish (US)
JournalTranscription
Volume4
Issue number2
DOIs
StatePublished - 2013

Keywords

  • DNA-scanning
  • Dynamics
  • Gene control
  • Kinetics
  • Target search
  • Zinc-finger nucleases
  • Zinc-finger transcription factors

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Biotechnology

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