Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species

X. Pourrut; A. Délicat; P. E. Rollin; T. G. Ksiazek; J. P. Gonzalez; E. M. Leroy

doi:10.1086/520541

Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species

X. Pourrut, A. Délicat, P. E. Rollin, T. G. Ksiazek, J. P. Gonzalez, E. M. Leroy

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

To characterize the distribution of Zaire ebolavirus (ZEBOV) infection within the 3 bat species (Epomops franqueti, Hypsignathus monstrosus, and Myonycteris torquata) that are possible reservoirs, we collected 1390 bats during 2003-2006 in Gabon and the Republic of the Congo. Detection of ZEBOV immunoglobulin G (IgG) in 40 specimens supports the role of these bat species as the ZEBOV reservoirs. ZEBOV IgG prevalence rates (5%) were homogeneous across epidemic and nonepidemic regions during outbreaks, indicating that infected bats may well be present in nonepidemic regions of central Africa. ZEBOV IgG prevalence decreased, significantly, to 1% after the outbreaks, suggesting that the percentage of IgG-positive bats is associated with virus transmission to other animal species and outbreak appearance. The large number of ZEBOV IgG-positive adult bats and pregnant H. monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks.

Original language	English (US)
Pages (from-to)	S176-S183
Journal	Journal of Infectious Diseases
Volume	196
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1086/520541
State	Published - Nov 15 2007
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/520541

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@article{dac54cfb94c9474b8ee196a94fd14ddf,

title = "Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species",

abstract = "To characterize the distribution of Zaire ebolavirus (ZEBOV) infection within the 3 bat species (Epomops franqueti, Hypsignathus monstrosus, and Myonycteris torquata) that are possible reservoirs, we collected 1390 bats during 2003-2006 in Gabon and the Republic of the Congo. Detection of ZEBOV immunoglobulin G (IgG) in 40 specimens supports the role of these bat species as the ZEBOV reservoirs. ZEBOV IgG prevalence rates (5%) were homogeneous across epidemic and nonepidemic regions during outbreaks, indicating that infected bats may well be present in nonepidemic regions of central Africa. ZEBOV IgG prevalence decreased, significantly, to 1% after the outbreaks, suggesting that the percentage of IgG-positive bats is associated with virus transmission to other animal species and outbreak appearance. The large number of ZEBOV IgG-positive adult bats and pregnant H. monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks.",

author = "X. Pourrut and A. D{\'e}licat and Rollin, {P. E.} and Ksiazek, {T. G.} and Gonzalez, {J. P.} and Leroy, {E. M.}",

note = "Funding Information: Supplement sponsorship. This article was published as part of a supplement entitled “Filoviruses: Recent Advances and Future Challenges,” sponsored by the Public Health Agency of Canada, the National Institutes of Health, the Canadian Institutes of Health Research, Cangene, CUH2A, Smith Carter, Hemisphere Engineering, Crucell, and the International Centre for Infectious Diseases. Funding Information: Financial support: Centre International de Recherches M{\'e}dicales de Franceville (CIRMF) is supported by the Government of Gabon, Total-Fina-Elf Gabon, and the Minist{\`e}re de la Coop{\'e}ration Franc¸aise. This work was also supported by a Fonds de Solidarit{\'e} Prioritaire grant from the Minist{\`e}re des Affaires Etrang{\`e}res de la France (FSP no. 2002005700). Supplement sponsorship is detailed in the Acknowledgments.",

year = "2007",

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doi = "10.1086/520541",

language = "English (US)",

volume = "196",

pages = "S176--S183",

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T1 - Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species

AU - Pourrut, X.

AU - Délicat, A.

AU - Rollin, P. E.

AU - Ksiazek, T. G.

AU - Gonzalez, J. P.

AU - Leroy, E. M.

N1 - Funding Information: Supplement sponsorship. This article was published as part of a supplement entitled “Filoviruses: Recent Advances and Future Challenges,” sponsored by the Public Health Agency of Canada, the National Institutes of Health, the Canadian Institutes of Health Research, Cangene, CUH2A, Smith Carter, Hemisphere Engineering, Crucell, and the International Centre for Infectious Diseases. Funding Information: Financial support: Centre International de Recherches Médicales de Franceville (CIRMF) is supported by the Government of Gabon, Total-Fina-Elf Gabon, and the Ministère de la Coopération Franc¸aise. This work was also supported by a Fonds de Solidarité Prioritaire grant from the Ministère des Affaires Etrangères de la France (FSP no. 2002005700). Supplement sponsorship is detailed in the Acknowledgments.

PY - 2007/11/15

Y1 - 2007/11/15

N2 - To characterize the distribution of Zaire ebolavirus (ZEBOV) infection within the 3 bat species (Epomops franqueti, Hypsignathus monstrosus, and Myonycteris torquata) that are possible reservoirs, we collected 1390 bats during 2003-2006 in Gabon and the Republic of the Congo. Detection of ZEBOV immunoglobulin G (IgG) in 40 specimens supports the role of these bat species as the ZEBOV reservoirs. ZEBOV IgG prevalence rates (5%) were homogeneous across epidemic and nonepidemic regions during outbreaks, indicating that infected bats may well be present in nonepidemic regions of central Africa. ZEBOV IgG prevalence decreased, significantly, to 1% after the outbreaks, suggesting that the percentage of IgG-positive bats is associated with virus transmission to other animal species and outbreak appearance. The large number of ZEBOV IgG-positive adult bats and pregnant H. monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks.

AB - To characterize the distribution of Zaire ebolavirus (ZEBOV) infection within the 3 bat species (Epomops franqueti, Hypsignathus monstrosus, and Myonycteris torquata) that are possible reservoirs, we collected 1390 bats during 2003-2006 in Gabon and the Republic of the Congo. Detection of ZEBOV immunoglobulin G (IgG) in 40 specimens supports the role of these bat species as the ZEBOV reservoirs. ZEBOV IgG prevalence rates (5%) were homogeneous across epidemic and nonepidemic regions during outbreaks, indicating that infected bats may well be present in nonepidemic regions of central Africa. ZEBOV IgG prevalence decreased, significantly, to 1% after the outbreaks, suggesting that the percentage of IgG-positive bats is associated with virus transmission to other animal species and outbreak appearance. The large number of ZEBOV IgG-positive adult bats and pregnant H. monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks.

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IS - SUPPL. 2

ER -

Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species

Abstract

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