Small volume resuscitation of hypovolemia using hypertonic saline-hemoglobin

G. C. Kramer, C. E. Wade, M. R.E. Silva

Research output: Contribution to journalConference articlepeer-review


The effects of hypertonic saline-hemoglobin on cardiac output, volume expansion, and oxygen delivery in hemorrhagic shock was modeled. Effective prehospital resuscitation of moderate hemorrhage was not achieved with Hb solution because cardiac output was only modestly increased and hematocrit was reduced. Hb solutions for the initial treatment of trauma will require infusion of large volumes, or combining the hyperoncotic Hb with a hyperosmotic crystalloid in order to be effective.

Original languageEnglish (US)
Pages (from-to)A119
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Issue number5
StatePublished - Nov 1994
EventProceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA
Duration: Jul 24 1994Jul 27 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering


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