Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth

Guoyang Luo, Thomas Morgan, Mert O. Bahtiyar, Victoria V. Snegovskikh, Frederick Schatz, Edward Kuczynski, Edmund F. Funai, Antonette T. Dulay, Se Te Joseph Huang, Catalin S. Buhimschi, Irina A. Buhimschi, Stephen J. Fortunato, Ramkumar Menon, Charles J. Lockwood, Errol R. Norwitz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Progesterone supplementation can prevent preterm birth in some high-risk women. Progesterone binds to progesterone receptor (PR) and modulates the expression of target genes. This study investigates the association between single nucleotide polymorphisms (SNPs) in the PR gene and spontaneous preterm birth. DNA was extracted from consecutive patients with preterm birth (n = 78) and term controls (n = 415), and genotyping was performed for 3 PR SNPs (+331[G>A], + 770[C>T], +660[G>T]) using Sequenom matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Data were analyzed by χ2 test and logistic regression analysis. Multivariate analysis showed no association between maternal carriage of minor + 331T, +770T, and/or +660T alleles and preterm birth when controlled for maternal age, ethnicity, gravidity, parity, prior preterm birth, route of delivery, or neonatal outcome. Carriage of +770T and +660T (but not +331T) was associated with preterm birth in women with a body mass index <18.5 kg/m2 (relative risk, 10.8; 95% confidence interval, 1.4-82.6; P =.02). Maternal carriage of minor alleles of +331(G>A), +770(C>T), and +660(G> T) SNPs in the PR gene is not associated with spontaneous preterm birth.

Original languageEnglish (US)
Pages (from-to)147-155
Number of pages9
JournalReproductive Sciences
Issue number2
StatePublished - Feb 2008
Externally publishedYes


  • Human pregnancy
  • Preterm birth
  • Progesterone receptor
  • Progresterone
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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