Simultaneous measurements of total hemoglobin concentration and blood oxygenation with laser diode-based optoacoustic system

Irene Y. Petrov, Donald S. Prough, Yuriy Petrov, S. Nan Henkel, Roger Seeton, Rinat O. Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Noninvasive, accurate, continuous monitoring of multiple variables, including blood oxygenation, i.e. oxyhemoglobin saturation (SO2) and total hemoglobin concentration (THb) in both high acuity and low acuity environments would greatly facilitate prompt diagnosis and treatment of physiologic derangements. However, most of the existing techniques for patient monitoring are invasive, while noninvasive techniques often fail to provide accurate measurements. We built a compact, multi-wavelength, nanosecond, fiber-coupled laser diode-based optoacoustic system for noninvasive, accurate monitoring of blood SO2 and THb in veins and arteries. We tested the system by probing the radial artery of healthy volunteers. Using blood samples obtained by venipuncture, we also measured a reference THb for each volunteer. Moreover, the optoacoustic data were compared with that obtained from a commercially available noninvasive monitor for measurements of these variables. The optoacoustic system provided rapid, simultaneous, and continuous measurement of THb and SO2 with high precision. The obtained results are promising and we plan to further test the system in clinical studies and at conditions simulating circulatory shock.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2017
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781510605695
StatePublished - 2017
EventPhotons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
Duration: Jan 29 2017Feb 1 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotons Plus Ultrasound: Imaging and Sensing 2017
Country/TerritoryUnited States
CitySan Francisco


  • Laser diode
  • Monitoring
  • Noninvasive
  • Optoacoustic
  • Oxygenation
  • Photoacoustic
  • Total hemoglobin concentration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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